High-speed Imaging reveals neurophysiological links to behavior in an animal model of depression
High-speed Imaging reveals neurophysiological links to behavior in an animal model of depression
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DOI：
10.1126/science.1144400
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发表时间：
2007-08-10
期刊：
影响因子：
56.9
通讯作者：
Deisseroth, Karl
中科院分区：
文献类型：
--
作者：
Airan, Raag D.;Meltzer, Leslie A.;Deisseroth, Karl
海马体是被认为在情感行为中发挥核心作用的几个大脑区域之一，但底层的局部网络动力学尚不清楚。我们使用定量电压敏感染料成像探测海马动力学与毫秒分辨率脑切片双向调制后的情感状态在抑郁症大鼠模型。我们发现，一个简单的措施，实时活动刺激诱发渗透活动通过齿状回相对于海马输出子字段占诱导的动物行为的变化独立的治疗的基本机制。我们的研究结果定义了情感行为的回路水平神经生理学内表型，并提出了一种理解精神疾病症状的回路水平底物的方法。
The hippocampus is one of several brain areas thought to play a central role in affective behaviors, but the underlying local network dynamics are not understood. We used quantitative voltage-sensitive dye imaging to probe hippocampal dynamics with millisecond resolution in brain slices after bidirectional modulation of affective state in rat models of depression. We found that a simple measure of real-time activity-stimulus-evoked percolation of activity through the dentate gyrus relative to the hippocampal output subfield-accounted for induced changes in animal behavior independent of the underlying mechanism of action of the treatments. Our results define a circuit-level neurophysiological endophenotype for affective behavior and suggest an approach to understanding circuit-level substrates underlying psychiatric disease symptoms.