Retrotransposon insertion targeting: a mechanism for homogenization of centromere sequences on nonhomologous chromosomes
Retrotransposon insertion targeting: a mechanism for homogenization of centromere sequences on nonhomologous chromosomes
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DOI：
10.1101/gad.191049.112
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发表时间：
2012-04-01
影响因子：
10.5
通讯作者：
Presting, Gernot G.
中科院分区：
文献类型：
--
作者：
Birchler, James A.;Presting, Gernot G.
大多数真核生物的着丝粒由高度重复的阵列组成，这些阵列在非同源染色体上是相似的。这些序列进化得很快，因此提出了一个关于如何使这些阵列同质化的谜团。最近在发生着丝粒富含反转录转座子的物种中的研究表明，这些元件优先插入着丝粒区域。在两个不同的拟南芥物种中，发现了一个相关的元件，其中这种靶向的特异性发生了改变。这些观察为着丝粒DNA序列同质化的发生提供了部分解释。
The centromeres of most eukaryotic organisms consist of highly repetitive arrays that are similar across non-homologous chromosomes. These sequences evolve rapidly, thus posing a mystery as to how such arrays can be homogenized. Recent work in species in which centromere-enriched retrotransposons occur indicates that these elements preferentially insert into the centromeric regions. In two different Arabidopsis species, a related element was recognized in which the specificity for such targeting was altered. These observations provide a partial explanation for how homogenization of centromere DNA sequences occurs.