Associations of weight loss and changes in fat distribution with the remission of hypertension in a bi-ethnic cohort: the Atherosclerosis Risk in Communities Study
Associations of weight loss and changes in fat distribution with the remission of hypertension in a bi-ethnic cohort: the Atherosclerosis Risk in Communities Study
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DOI：
10.1016/s0091-7435(02)00063-4
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发表时间：
2003-03-01
影响因子：
5.1
通讯作者：
Cai, JW
中科院分区：
文献类型：
--
作者：
Juhaeri;Stevens, J;Cai, JW
背景。在以社区为基础的样本中，研究体重减轻和脂肪分布变化与血压变化和高血压缓解的关系。参与者是3245名白人和非裔美国人，年龄在45-64岁之间，他们参加了社区动脉粥样硬化风险研究，平均时间为9年。使用混合模型分析来检查体重减轻和脂肪分布变化与血压变化之间的关系。采用具有时间相关协变量的比例风险模型来检验体重减轻和脂肪分布变化与高血压缓解的关系。体重减轻与收缩压和舒张压的降低以及高血压缓解率的增加有关。白人女性、非裔美国女性、白人男性和非裔美国男性的高血压缓解与年减重增加1公斤相关的风险比分别为2.04（95%可信区间[CI]: 1.62-2.59）、1.38 （95% CI: 1.14-1.67）、1.84 （95% CI: 1.47-2.29）和1.53 （95% CI: 1.14-2.05）。脂肪分布的改变与年轻参与者（45-54岁）高血压的缓解有关。在白人和非裔美国男性和女性中，体重减轻与血压降低和高血压缓解有关。(C) 2003年美国卫生基金会和爱思唯尔科学（美国）。版权所有。
Background. To examine associations of weight loss and changes in fat distribution with changes in blood pressure and the remission of hypertension in a community-based sample.Methods. Participants were 3245 white and African-American men and women, 45-64 years of age, who participated in the Atherosclerosis Risk in Communities Study over an average of 9 years. Mixed models analyses were used to examine the associations of weight loss and changes in fat distribution with changes in blood pressure. Proportional hazard models with time-dependent covariates were used to examine the associations of weight loss and changes in fat distribution with the remission of hypertension.Results. Weight loss was associated with a decrease in systolic blood pressure and diastolic blood pressure and with an increased rate of remission of hypertension. Hazard ratios of the remission of hypertension associated with 1-kg increment in annual weight loss were 2.04 (95% confidence interval [CI]: 1.62-2.59), 1.38 (95% CI: 1.14-1.67), 1.84 (95% CI: 1.47-2.29), and 1.53 (95% CI: 1.14-2.05) for white women, African-American women, white men, and African-American men, respectively. Changes in fat distribution were associated with the remission of hypertension in younger (45-54 years) participants.Conclusions. Weight loss was associated with a decrease in blood pressure and with remission of hypertension in white and African-American men and women. (C) 2003 American Health Foundation and Elsevier Science (USA). All rights reserved.