Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus
Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus
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DOI：
10.1128/jvi.01757-07
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发表时间：
2008-02-01
影响因子：
5.4
通讯作者：
Fox, Howard S.
中科院分区：
文献类型：
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作者：
Gaskill, Peter J.;Zandonatti, Michelle;Fox, Howard S.
人类免疫缺陷病毒(HIV)和猴免疫缺陷病毒(SIV)感染巨噬细胞和T淋巴细胞并进行高效复制。在这里，我们展示了来自巨噬细胞的SIV病毒粒子比来自T细胞的病毒粒子具有更高的传染性水平。T细胞衍生病毒的低传染性受病毒粒子上甘露糖残基的数量或类型的影响。我们的结果表明，病毒的细胞来源是病毒传染性的主要因素。病毒感染性中的细胞类型特异性因素，以及特定器官或疾病阶段特定的病毒粒子细胞来源的差异，在艾滋病毒和艾滋病的发病机制中可能是至关重要的。
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infect and productively replicate in macrophages and T lymphocytes. Here, we show that SIV virions derived from macrophages have higher levels of infectivity than those derived from T cells. The lower infectivity of T-cell-derived viruses is influenced by the quantity or type of mannose residues on the virion. Our results demonstrate that the cellular origin of a virus is a major factor in viral infectivity. Cell-type-specific factors in viral infectivity, and organ-specific or disease stage-specific differences in cellular derivation of virions, can be critical in the pathogenesis of HIV and AIDS.