NaOCl-mediated biofunctionalization enhances bone-titanium integration.
NaOCl-mediated biofunctionalization enhances bone-titanium integration.
复制标题
NaOCl 介导的生物功能化增强了骨-钛整合。
DOI：
10.4012/dmj.2015-010
复制
发表时间：
2015
影响因子：
2.5
通讯作者：
H. Koshino
中科院分区：
文献类型：
--
作者：
Mai Kono;H. Aita;Yuki Ichioka;T. Kado;K. Endo;H. Koshino
本研究的目的是检查在大鼠模型的早期愈合阶段NaOCl预处理对种植体生物力学固定的影响。制备抛光钛圆柱形植入物和圆盘，并对这些样品的一半进行双酸蚀刻。然后，通过用5%NaOCl溶液预处理24小时来化学清洁两个表面的一半。形态学分析表明，NaOCl处理前后的细胞形态无显著差异。润湿性的测量表明，次氯酸钠处理钛表面从疏水性转化为超亲水性，伴随着从钛表面的碳氢化合物的去除。生物力学推入测试表明，NaOCl处理的植入物的骨-钛结合强度明显大于未处理的植入物（p<0.05）。这些结果表明，NaOCl预处理增强了钛的骨整合能力，表明其作为一种简单的化学椅旁预处理方法的潜力。
The aim of this study was to examine the effect of NaOCl pretreatment on the biomechanical fixation of implant at the early healing stage of a rat model. Polished titanium cylindrical implants and disks were prepared, and one-half of these samples were dual acidetched. Then, one-half of both surfaces were chemically-cleaned by pretreatment with 5% NaOCl solution for 24 h. Morphological analyses showed that there was no significant difference between before and after NaOCl treatment. The wettability measurement demonstrated that NaOCl treatment secondarily converted both titanium surfaces from hydrophobic to superhydrophilic, accompanied by the removal of hydrocarbons from the titanium surfaces. Biomechanical push-in test indicated that the bone-titanium integration strength of the NaOCl-treated implants were significantly greater than that of the untreated implants (p<0.05). These results showed that NaOCl pretreatment enhanced the osseointegration capability of titanium, indicating its potential for a simple chemical chair-side pretreatment method.