HISTOGENESIS OF PRIMARY LOCALIZED CUTANEOUS AMYLOIDOSIS - SEQUENTIAL CHANGE OF EPIDERMAL KERATINOCYTES TO AMYLOID VIA FILAMENTOUS DEGENERATION
HISTOGENESIS OF PRIMARY LOCALIZED CUTANEOUS AMYLOIDOSIS - SEQUENTIAL CHANGE OF EPIDERMAL KERATINOCYTES TO AMYLOID VIA FILAMENTOUS DEGENERATION
复制标题
DOI：
10.1111/1523-1747.ep12581609
复制
发表时间：
1979-01-01
影响因子：
6.5
通讯作者：
HASHIMOTO, K
中科院分区：
文献类型：
--
作者：
KUMAKIRI, M;HASHIMOTO, K
电镜检查2例地衣淀粉样变和8例黄斑淀粉样变。表皮角化细胞在基底或下马氏层表现出不同程度的局灶变性。原发变化见于含有纤维状（30纳米厚）细胞质包涵体的细胞。以下的发展似乎导致了丝状变性（胶质体）：颗粒状或纤维状细胞质中的张力丝聚集，丝状细胞由被细胞膜和桥粒包围的7纳米厚的丝束组成，细胞间隙中由7纳米厚的丝束或螺旋组成的丝状团块。在真皮与表皮交界处，一些丝状团块被表皮的基底层包围，另一些丝状团块则落入真皮层。偶尔，松散的纤维（类似于淀粉样纤维）即将落入真皮层。淀粉样蛋白岛的早期形成由电子密集部分和电子轻部分组成。它们位于表皮的正下方。在乳头状真皮的较深部分和网状真皮的上部，大多数是电子轻肿块。电子密集部分为密集排列的7 nm厚的细丝，而电子轻部分为典型的直淀粉样蛋白细丝。丝状细胞、丝状团块和淀粉样岛中可见小管状丝。原发性局部形式的皮肤淀粉样病变中的一些淀粉样物质是通过丝状变性从表皮细胞中产生的。
Two [human] cases of lichen amyloidosus and 8 cases of macular amyloidosis were examined by EM. Epidermal keratinocytes showed variable degrees of focal degeneration in the basal or lower Malpighian layer. The primary change was seen in cells which contain fibrillar (30 nm in thickness) cytoplasmic inclusion. The following developments seemed to lead to filamentous degeneration (colloid bodies): aggregation of tonofilaments within the granular or fibrillar cytoplasm, filamentous cells which are composed of bundles of 7 nm thick filaments surrounded by cell membrane and desmosomes and filamentous masses composed of bundles or whorls of tightly packed 7 nm thick filaments in the intercellular spaces. At the dermo-epidermal junction some of the filamentous masses were surrounded by the basal lamina of the epidermis and others were dropping into the dermis. Occasionally, loosened filaments (similar to amyloid filaments) were about to drop into the dermis. Early formation of amyloid islands consisted of electron-dense and electron-light parts. They were located directly beneath the epidermis. In the deeper portion of the papillary dermis and in the upper reticular dermis the majority were electron-light masses. Electron dense parts were the densely packed 7 nm thick filaments, whereas electron-light parts were the typical straight amyloid filaments. Small tubular filaments were seen in common in the filamentous cells, filamentous masses and amyloid islands. Some of the amyloid substance in primary localized forms of cutaneous amyloidoses derive from the epidermal cells through filamentous degeneration.