Hemophagocytic lymphohistiocytosis (HLH) secondary to disseminated histoplasmosis in the setting of Acquired Immunodeficiency Syndrome (AIDS)
Hemophagocytic lymphohistiocytosis (HLH) secondary to disseminated histoplasmosis in the setting of Acquired Immunodeficiency Syndrome (AIDS)
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DOI：
10.1016/j.mmcr.2018.01.001
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发表时间：
2018-06-01
影响因子：
2.2
通讯作者：
Ramirez, Veronica
中科院分区：
文献类型：
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作者：
Asanad, Samuel;Cerk, Brendan;Ramirez, Veronica
噬血细胞性淋巴组织细胞增生症（HLH）是一种罕见的侵袭性疾病，涉及免疫系统过度激活导致噬血细胞。HLH需要早期诊断和及时治疗，特别是在获得性免疫缺陷综合征（AIDS）患者中。我们报告一位罹患爱滋病并合并肾衰竭的中年男性，因播散性组织胞浆菌病而发展为HLH。HLH 2004指南推荐的依托泊苷化疗被推迟，治疗重点改为抗真菌治疗。随后进行了抗逆转录病毒治疗。
Hemophagocytic lymphohistiocytosis (HLH) is a rare and aggressive disease involving immune system overactivation leading to hemophagocytosis. HLH requires early diagnosis and prompt treatment initiation, especially in patients with Acquired Immunodeficiency Syndrome (AIDS). We present a case of a middle-aged male with AIDS and renal failure, who developed HLH secondary to disseminated histoplasmosis. Etoposide chemotherapy as recommended by the HLH 2004 Guidelines was deferred and treatment focused instead on antifungal therapy. Anti-retroviral therapy followed thereafter.