Risk factor analysis of bone metastasis in patients with non-small cell lung cancer.
Risk factor analysis of bone metastasis in patients with non-small cell lung cancer.
复制标题
非小细胞肺癌骨转移危险因素分析
DOI：
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发表时间：
2022
影响因子：
2.2
通讯作者：
Qiquan Yu
中科院分区：
文献类型：
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作者：
Yang Li;Chongqing Xu;Qiquan Yu
目的
骨组织是除肺和肝外最常见的转移部位。30%~40%的非小细胞肺癌（non-small cell lung cancer，NSCLC）患者在疾病发展过程中会发生骨转移（bone metastasis，BM）。本研究旨在通过多因素分析探讨非小细胞肺癌的相关危险因素，为预防非小细胞肺癌的骨髓及骨相关事件提供依据。
方法
我们分析了152例患者，其中BM组67例，非BM组85例。对两组患者的一般临床资料和实验室指标（主要是凝血功能）进行单因素和多因素分析。筛选出NSCLC患者BM的独立危险因素。
结果
单因素分析结果显示，血栓形成、临床分期、肿瘤淋巴结转移（TNM）分期、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、纤维蛋白原（FIB）、D-二聚体（D-D）、血小板（PLT）、碱性磷酸酶（AKP）是NSCLC患者BM的危险因素（p<0.05）。多因素Logistic回归分析显示，临床Ⅲ ~ Ⅳ期、TNM分期T1 ~ T3、N2 ~ N3、FIB、APTT、D-D、AKP是NSCLC患者BM的独立危险因素（P<0.05）。
结论
临床分期III-IV、TNM分期T1-T3、TNM分期N2-N3、FIB、APTT、D-D和AKP是NSCLC患者BM的独立危险因素。同时，对存在这些危险因素的患者应及时进行筛查，对预防骨相关事件、缓解疼痛具有重要意义。
OBJECTIVE
Bone tissue is the most common metastatic location besides lung and liver. 30%~40% of patients with non-small cell lung cancer (NSCLC) will have bone metastasis (BM) in the development of the disease. This study aims to explore the relevant risk factors through multivariate analysis, in order to provide basis for the prevention of BM and bone related events of NSCLC.
METHODS
We analyzed 152 patients, with 67 in BM group and 85 in non-BM group. The general clinical data and laboratory indicators (mainly coagulation function) of patients were compared through univariate and multivarijate analysis. Finally, the independent risk factors of BM in patients with NSCLC were screened out.
RESULTS
The results of univariate analysis show that thrombosis, clinical stage, tumor-node-metastasis (TNM) stage, prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB), D-Dimer (D-D), platelet (PLT) and alkaline phosphatase (AKP) are the risk factors of BM in patients with NSCLC (p<0.05). Further multivariate logistic regression analysis suggests that the independent risk factors of BM in patients with NSCLC are clinical stage III-IV, TNM stage T1-T3, TNM stage N2-N3, FIB, APTT, D-D and AKP (P<0.05).
CONCLUSION
Clinical stage III-IV, TNM stage T1-T3, TNM stage N2-N3, FIB, APTT, D-D and AKP are the independent risk factors of BM in patients with NSCLC. Meanwhile, patients with these risk factors should be screened in time, which is of great significance to prevent bone related events and relieve pain.