Dietary advanced glycation end products and the risk of postmenopausal breast cancer in the National Institutes of Health-AARP Diet and Health Study
Dietary advanced glycation end products and the risk of postmenopausal breast cancer in the National Institutes of Health-AARP Diet and Health Study
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DOI：
10.1002/cncr.32798
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发表时间：
2020-02-25
期刊：
影响因子：
6.2
通讯作者：
Turner, David P.
中科院分区：
文献类型：
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作者：
Peterson, Lindsay L.;Park, Seho;Turner, David P.
研究背景晚期糖基化终末产物(AGEs)是糖代谢的副产物，在高脂肪和深加工食品中通过饮食摄入。它们与慢性炎症性疾病有关，有证据表明它们在癌症的发生中发挥了作用。作者评估了饮食年龄摄入与绝经后浸润性乳腺癌风险的关系。方法这是一项前瞻性队列研究，研究对象为美国国立卫生研究院-美国退休人员协会饮食与健康研究中的183,548名绝经后妇女。主要结果是发生浸润性乳腺癌。年龄摄入量是根据食物频率调查问卷估计的。发生的乳腺癌病例是通过州癌症登记确定的。COX比例风险回归模型被用来估计根据年龄摄入量五分位数发生乳腺癌的危险比(HR)和95%可信区间。结果平均随访时间为12.8年，确诊乳腺癌9851例(1978年晚期)。每日摄入量的中位数为每100千卡(KU/1000千卡)5932千克单位。摄入量较高的女性往往受教育程度较低，体重指数较高，体力活动较少，目前吸烟，脂肪和肉类摄入量较高。年龄摄入量最高的五分之一(与最低的相比)与乳腺癌风险增加(HR，1.09；95%CI，1.02~1.16；P=.03)相关，特别是与37%的晚期肿瘤相关(HR，1.37；95%CI，1.09~1.74；P<；0.02)。结论饮食年龄可能在绝经后乳腺癌的发生中起作用。
Background Advanced glycation end products (AGEs) are reactive metabolites produced as a by-product of sugar metabolism and are consumed through the diet in high-fat and highly processed foods. They are associated with chronic inflammatory diseases, and evidence suggests that they play a role in carcinogenesis. The authors evaluated the association of dietary AGE intake and the risk of postmenopausal invasive breast cancer.Methods This was a prospective cohort study of 183,548 postmenopausal women in the National Institutes of Health-AARP Diet and Health Study. The main outcome was incident invasive breast cancer. AGE intake was estimated from food-frequency questionnaires. Incident breast cancer cases were identified through state cancer registries. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals for developing breast cancer according to AGE intake quintiles. Multivariable regression models were adjusted for breast cancer risk factors.Results The mean follow-up was 12.8 years, and 9851 breast cancers (1978 advanced stage) were identified. The median AGE daily intake was 5932 kilo units per 100 kilocalories (KU/1000 kcal). Women with higher intake tended to have lower education levels, higher body mass index, less physical activity, were current smokers, and had higher fat and meat intake. The highest quintile of AGE intake (compared with the lowest) was associated with an increased risk of breast cancer (HR, 1.09; 95% CI, 1.02-1.16; P = .03) after adjusting for breast cancer risk factors and particularly was associated with 37% of advanced-stage tumors (HR, 1.37; 95% CI, 1.09-1.74; P < .02) after adjusting for risk factors and fat and meat intake.Conclusions Dietary AGEs may play a role in the development of postmenopausal breast cancer.