The biology of aging in a social world: Insights from free-ranging rhesus macaques
The biology of aging in a social world: Insights from free-ranging rhesus macaques
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DOI：
10.1016/j.neubiorev.2023.105424
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发表时间：
2023-10-23
影响因子：
8.2
通讯作者：
Highama，James P.
中科院分区：
文献类型：
--
作者：
Newman，Laura E.;Testard，Camille;Highama，James P.
社会逆境可以增加与年龄相关的疾病和死亡风险，然而，将社会逆境与衰老联系起来的生物学机制仍然知之甚少。对非人类动物进行长期的自然研究对于将个体一生的社会行为观察与详细的解剖、生理和分子测量相结合至关重要。在这里，我们综合了这样一个自然主义研究系统的研究主体，圣地亚哥岛是世界上持续监测时间最长的自由放养恒河猴（Macaca mulatta）种群的家园。我们回顾了最近在形态学、基因调控、微生物组组成和免疫功能方面的研究。我们还讨论了这一人群中年龄标记的生态和社会修饰因素。特别是，我们总结了重大自然灾害玛丽亚飓风如何影响恒河猴的生理和社会结构，并强调了衰老修饰词的上下文依赖性和领域特异性。最后，我们为未来在圣地亚哥岛和其他地方的研究提供了方向，这将进一步加深我们对不同领域老龄化的理解，以及社会逆境如何改变老龄化过程。
Social adversity can increase the age-associated risk of disease and death, yet the biological mechanisms that link social adversities to aging remain poorly understood. Long-term naturalistic studies of nonhuman animals are crucial for integrating observations of social behavior throughout an individual’s life with detailed anatomical, physiological, and molecular measurements. Here, we synthesize the body of research from one such naturalistic study system, Cayo Santiago, which is home to the world’s longest continuously monitored free-ranging population of rhesus macaques(Macaca mulatta). We review recent studies of age-related variation in morphology, gene regulation, microbiome composition, and immune function. We also discuss ecological and social modifiers of age-markers in this population. In particular, we summarize how a major natural disaster, Hurricane Maria, affected rhesus macaque physiology and social structure and highlight the context-dependent and domain-specific nature of aging modifiers. Finally, we conclude by providing directions for future study, on Cayo Santiago and elsewhere, that will further our understanding of aging across different domains and how social adversity modifies aging processes.