Serum gamma-glutamyltransferase activity and Parkinson's disease risk in men and women
Serum gamma-glutamyltransferase activity and Parkinson's disease risk in men and women
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DOI：
10.1038/s41598-020-58306-x
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发表时间：
2020-01-27
影响因子：
4.6
通讯作者：
Lee, Jee-Young
中科院分区：
文献类型：
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作者：
Yoo, Dallah;Kim, Ryul;Lee, Jee-Young
我们评估了血清谷氨酰转移酶(GGT)和帕金森病(PD)的风险。使用国民健康保险服务(NHIS)数据库的数据，我们构建了一个由40岁以上的个人组成的队列，这些人在2009年进行了健康检查。在排除了大量饮酒、肝胆和胰腺疾病以及既往帕金森病病史的个体后，对基线血清GGT水平的每四分位数组进行了7年的帕金森病发展监测。校正潜在混杂变量的Cox比例风险模型估计了PD的调整风险比(HR)。此外，我们还分析了GGT与肥胖或代谢综合征之间可能的相互作用。在纳入的6,098,405人中，20,895人在随访期间发展为帕金森病(0.34%，9,512名男性和11,383名女性)。以血清GGT的低四分位数为参照，血清GGT的高四分位数(几何均值，男性为90.44IU/L，女性为41.86IU/L)与男性较低的风险(校正后HR=0.72(95%CI：0.67~0.76))和女性的较高风险(调整后HR=1.30(95%CI：1.23~1.37))相关。肥胖和代谢综合征增加了男女患帕金森病的风险，在女性中，血清GGT和肥胖之间只存在亚加性交互作用。
We evaluated serum gamma-glutamyltransferase (GGT) and the risk of Parkinson's disease (PD). Using data from the National Health Insurance Service (NHIS) database, we constructed a cohort consisting of individuals aged above 40 years who underwent a health check-up in 2009. After excluding individuals with heavy alcohol consumption, hepatobiliary and pancreatic disorders, and a previous history of PD, each quartile group of baseline serum GGT levels was monitored for the development of PD for 7 years. Adjusted hazard ratios (HRs) for PD were estimated by Cox proportional hazard models adjusting for potential confounding variables. We additionally analyzed the possible interaction between GGT and obesity or metabolic syndrome. Among the 6,098,405 individuals who were included, PD developed in 20,895 individuals during the follow-up (0.34%, 9,512 men and 11,383 women). The top quartile of serum GGT (geometric means, 90.44 IU/L in men and 41.86 IU/L in women) was associated with a lower risk in men (adjusted HR=0.72 (95% CI: 0.67-0.76)) and a higher risk in women (adjusted HR=1.30 (95% CI: 1.23-1.37)) using the lower GGT quartiles as a reference. Obesity and metabolic syndrome increased PD risk in both sexes, and there was only a subadditive interaction between serum GGT and obesity in women.