Cytotoxic alkaloids and a flavan from the bulbs of Crinum asiaticum var. japonicum.
Cytotoxic alkaloids and a flavan from the bulbs of Crinum asiaticum var. japonicum.
复制标题
DOI：
10.1248/cpb.49.1217
复制
发表时间：
2001-09
影响因子：
1.7
通讯作者：
Byung-Sun Min;Jiang-Jing Gao;Norio Nakamura;Young Ho Kim;Masao Hattori
中科院分区：
文献类型：
--
作者：
Byung-Sun Min;Jiang-Jing Gao;Norio Nakamura;Young Ho Kim;Masao Hattori
从亚洲红豆杉的鳞茎中分离得到一个新的吡咯苯乙酮类生物碱--洋葱毒碱A(1)。、石蒜碱(3)、4‘-羟基-7-甲氧基黄烷(4)。新生物碱的结构经波谱分析确定为4，5-亚乙基-9，10-二羟基-6-菲咯烷酮。用体外细胞毒实验测定了化合物1-4对小鼠肉瘤Meth-A和小鼠Lewis肺癌细胞株的细胞毒作用。此外，还检测了3与LLC肿瘤细胞的体内抗肿瘤活性。
A new pyrrolophenanthridone alkaloid, criasiaticidine A (1), was isolated from the bulbs of Crinum asiaticum var. japonicum, together with pratorimine (2), lycorine (3) and 4'-hydroxy-7-methoxyflavan (4). The structure of the new alkaloid was determined to be 4,5-etheno-9,10-dihydroxy-6-phenanthridone by spectroscopic means. The cytotoxicity of the isolated compounds 1-4 was evaluated in vitro against Meth-A (mouse sarcoma) and Lewis lung carcinoma (mouse lung carcinoma) tumor cell lines. Furthermore, 3 was examined for in vivo antitumor activity with LLC tumor cells.