Rheumatoid arthritis in Spain:: occurrence of extra-articular manifestations and estimates of disease severity
Rheumatoid arthritis in Spain:: occurrence of extra-articular manifestations and estimates of disease severity
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DOI：
10.1136/ard.62.9.897
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发表时间：
2003-09-01
影响因子：
27.4
通讯作者：
Sanmartí, R
中科院分区：
文献类型：
--
作者：
Carmona, L;González-Alvaro, I;Sanmartí, R
目的：通过估计平均临床活动、功能能力、放射学损伤以及关节外表现的当前和累积患病率，来描述西班牙患者样本中的 RA 特征。方法：对从 34 个中心的临床数据库中随机选择的 RA 患者队列进行横断面分析。使用标准定义和测量，并集中读取射线照片。根据抽样调整估计值和置信区间。结果：788 名患者的数据可用。 285 名 (36.2%) 患者存在关节外 RA。估计了关节外表现的累积患病率和 95% 置信区间：结节 24.5%（21.5 至 27.5）、干燥综合征 17.0%（14.4 至 19.6）、寰枢椎半脱位 12.1%（9.8 至 14.4）、腕管综合征 10.7%（7.8 至 13.6）、间质性肺病 3.7%（2.4 至 5.0）、浆膜炎 2.5%（1.4 至 3.5）、眼病 2.5%（1.1 至 3.9）、血管炎 1.3%（0.5 至 2.1）、淀粉样变性 0.6%（0.1 至 1.2）和费尔蒂综合征 0.3%（
Objectives: To characterise RA in a sample of Spanish patients by estimating mean clinical activity, functional ability, and radiological damage, and current and cumulative prevalence of extra-articular manifestations.Methods: Cross sectional analysis of a cohort of patients with RA randomly selected from the clinical databases of 34 centres. Standard definitions and measurements were used, and radiographs read centrally. Estimates and confidence intervals were adjusted to sampling.Results: Data were available for 788 patients. Extra-articular RA was present in 285 (36.2%) patients. Cumulative prevalence and 95% confidence intervals of extra-articular manifestations were estimated: nodules 24.5% (21.5 to 27.5), Sjogren's syndrome 17.0% (14.4 to 19.6), atlantoaxial subluxation 12.1% (9.8 to 14.4), carpal tunnel syndrome 10.7% (7.8 to 13.6), interstitial lung disease 3.7% (2.4 to 5.0), serositis 2.5% (1.4 to 3.5), eye disease 2.5% (1.1 to 3.9), vasculitis 1.3% (0.5 to 2.1), amyloidosis 0.6% (0.1 to 1.2), and Felty's syndrome 0.3% (