Multiple micronutrient supplementation for improving cognitive performance in children: systematic review of randomized controlled trials
Multiple micronutrient supplementation for improving cognitive performance in children: systematic review of randomized controlled trials
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DOI：
10.3945/ajcn.2009.28376
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发表时间：
2010-01-01
影响因子：
7.1
通讯作者：
Osendarp, Saskia J. M.
中科院分区：
文献类型：
--
作者：
Eilander, Ans;Gera, Tarun;Osendarp, Saskia J. M.
背景资料：虽然多种微量营养素干预措施已被证明有利于儿童的智力发展，目前缺乏一个全面的评估的证据，以指导公共卫生policy.Objective：本研究旨在系统地回顾目前的文献，并量化多种微量营养素对学龄儿童认知能力的影响。检索了科学信息研究所知识网和当地医学数据库中1970年至2008年发表的试验。随机对照试验，研究>= 3种微量营养素与安慰剂相比对0-18岁健康儿童认知功能的影响。数据由2名独立研究人员提取。将试验中使用的认知测试分为几个认知领域（例如，液体智力和结晶智力），并计算每个领域的汇总效应量估计值。通过敏感性和荟萃回归技术探讨异质性。
Background: Although multiple micronutrient interventions have been shown to benefit children's intellectual development, a thorough evaluation of the totality of evidence is currently lacking to direct public health policy.Objective: This study aimed to systematically review the present literature and to quantify the effect of multiple micronutrients on cognitive performance in schoolchildren.Methods: The Institute for Scientific Information Web of Knowledge and local medical databases were searched for trials published from 1970 to 2008. Randomized controlled trials that investigated the effect of >= 3 micronutrients compared with placebo on cognition in healthy children aged 0-18 y were included following protocol. Data were extracted by 2 independent researchers. The cognitive tests used in the trials were grouped into several cognitive domains (eg, fluid and crystallized intelligence), and pooled effect size estimates were calculated per domain. Heterogeneity was explored through sensitivity and meta-regression techniques.Results: Three trials were retrieved in children aged