An Ultraflexible and Transparent Graphene-Based Wearable Sensor for Biofluid Biomarkers Detection
An Ultraflexible and Transparent Graphene-Based Wearable Sensor for Biofluid Biomarkers Detection
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DOI：
10.1002/admt.202101131
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发表时间：
2022-02-09
影响因子：
6.8
通讯作者：
Pan, Yunlu
中科院分区：
文献类型：
--
作者：
Huang, Cong;Hao, Zhuang;Pan, Yunlu
提出了一种用于检测体液生物标志物的超柔性和透明的石墨烯基场效应晶体管（GFET）可穿戴纳米传感器。纳米传感器用可以与生物标志物特异性结合的受体功能化，导致石墨烯的载体浓度的可检测变化。在从100个变形循环（在半径175 μ m处弯曲，在150度处折叠，并且在50%处收缩）恢复之后，没有观察到可见的机械损伤，并且纳米传感器的电性能也是高度一致的。选择与多种疾病相关的L-半胱氨酸作为生物标志物，以证明传感器的检测能力。该纳米传感器能够持续可靠地检测L-半胱氨酸，在未稀释的人体汗液中的检测限为0.022 x 10（-6）m，在人工泪液中的检测限为0.043 x 10（-6）m。该传感器由1 μ m的透明聚对苯二甲酸乙二醇酯基片和WO 3/Au/WO 3电极（透明度为81%）制成，可安装在眼球上进行泪液检测，不受视觉影响。这些结果表明，超柔性和透明的GFET可穿戴纳米传感器可能有助于医疗检测应用。
An ultraflexible and transparent graphene-based field-effect transistors (GFET) wearable nanosensor is presented for detection of body fluid-biomarkers. The nanosensor is functionalized with a receptor that can specifically bind with the biomarker, resulting in a detectable change in the carrier concentration of the graphene. After recovery from 100 cycles of deformations (bending at radii 175 mu m, folding at 150 degrees, and shrinking at 50%), no visible mechanical damage is observed, and electrical properties of the nanosensor are also highly consistent. L-cysteine, associated with various diseases, is chosen as the biomarker to demonstrate the detection capability of the sensor. The nanosensor is capable of consistently and reliably detecting L-cysteine with a limit of detection of 0.022 x 10(-6) m in undiluted human sweat and 0.043 x 10(-6) m in artificial tears. The sensor is fabricated from the 1 mu m transparent polyethylene glycol terephthalate substrate and WO3/Au/WO3 electrode (transparency of 81%), and it can be mounted on the eyeball in tear detection without visual influence. These results demonstrate that the ultraflexible and transparent GFET wearable nanosensor can potentially be helpful in medical detection applications.