Imaging methods for morphological and functional phenotyping of the rodent heart
Imaging methods for morphological and functional phenotyping of the rodent heart
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DOI：
10.1080/01926230500404126
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发表时间：
2006-01-01
影响因子：
1.5
通讯作者：
Johnson, GA
中科院分区：
文献类型：
--
作者：
Badea, CT;Bucholz, E;Johnson, GA
小动物成像在表型分析、药物发现和提供对疾病机制的基本理解方面具有关键作用。将成像方法从人类翻译到小动物并不是一件容易的事。这项工作的目的是比较两种心脏成像模式，即，磁共振显微镜（MRM）和微型计算机断层扫描（CT）用于啮齿动物的临床前研究。我们介绍了这两种技术，它们可以测量的参数，它们可以检测到的改变类型，并展示了这些成像方法与临床医学中可用的技术的比较。虽然本文本身并不涉及药物或化学品开发的心脏风险评估，但我们希望这些信息将有效地解决如何利用MRM和micro-CT来测量对安全性评估至关重要的生物标志物。
Small animal imaging has a critical role in phenotyping, drug discovery, and in providing a basic understanding of mechanisms of disease. Translating imaging methods from humans to small animals is not an easy task. The purpose of this work is to compare two cardiac imaging modalities, i.e., magnetic resonance microscopy (MRM) and microcomputed tomography (CT) for preclinical studies on rodents. We present the two technologies, the parameters that they can measure, the types of alterations that they can detect, and show how these imaging methods compare to techniques available in clinical medicine. While this paper does not refer per se to the cardiac risk assessment for drug or chemical development, we hope that the information will effectively address how MRM and micro-CT might be exploited to measure biomarkers critical for safety assessment.