Report of the First International Consensus on Standardized Nomenclature of Antinuclear Antibody HEp-2 Cell Patterns 2014-2015.
Report of the First International Consensus on Standardized Nomenclature of Antinuclear Antibody HEp-2 Cell Patterns 2014-2015.
复制标题
DOI：
10.3389/fimmu.2015.00412
复制
发表时间：
2015
影响因子：
7.3
通讯作者：
Andrade LE
中科院分区：
文献类型：
--
作者：
Chan EK;Damoiseaux J;Carballo OG;Conrad K;de Melo Cruvinel W;Francescantonio PL;Fritzler MJ;Garcia-De La Torre I;Herold M;Mimori T;Satoh M;von Mühlen CA;Andrade LE
在2014年8月28日于巴西圣保罗举行的第12届自身抗体和自身免疫国际研讨会期间，一整天的会议致力于建立对HEp-2细胞抗核抗体（ANA）间接免疫荧光试验中观察到的染色模式命名的共识。本报告总结了集体协议，并从东道国巴西和代表研究，临床和诊断服务实验室的国际社会的投入。模式分为三大类（细胞核，细胞质和有丝分裂模式），每种模式都有详细的定义和描述。共识命名法和代表性模式可在抗核抗体模式国际共识（ICAP）网站（）上在线获得。为了促进不断改进和投入，鼓励对会计师协会提出具体意见，这些意见将在会计师协会以后的会议上讨论。建立ICAP的最终目标是促进自身抗体检测术语的协调和理解，以及ANA检测的解释指南，从而优化患者护理中的使用。
During the 12th International Workshop on Autoantibodies and Autoimmunity held in Sao Paulo, Brazil, on August 28, 2014, a full day session was devoted to establishing a consensus on the nomenclature of staining patterns observed in the antinuclear antibody (ANA) indirect immunofluorescence test on HEp-2 cells. The current report summarizes the collective agreements with input from the host Brazilian and international communities that represented research, clinical, and diagnostic service laboratories. Patterns are categorized in three major groups (nuclear, cytoplasmic, and mitotic patterns) and each pattern has been defined and described in detail. The consensus nomenclature and representative patterns are made available online at the international consensus on antinuclear antibody pattern (ICAP) website (). To facilitate continuous improvement and input, specific comments on ICAP are encouraged and these will be discussed in subsequent ICAP meetings. The ultimate goal with the establishment of the ICAP is to promote harmonization and understanding of autoantibody test nomenclature, as well as interpretation guidelines for ANA testing, thereby optimizing usage in patient care.