A longitudinal study of offspring born to methadone-maintained women. I. Design, methodology, and description of women's resources for functioning.
A longitudinal study of offspring born to methadone-maintained women. I. Design, methodology, and description of women's resources for functioning.
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对接受美沙酮治疗的女性所生后代的纵向研究。
DOI：
10.3109/00952998409002778
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
A. Morris
中科院分区：
文献类型：
--
作者：
J. Marcus;S. Hans;C. Patterson;A. Morris
有一种假设认为，胎儿接触美沙酮的直接毒性效应会对儿童造成持久的伤害，为了检验这一假说的替代方案，我们设计了一项针对服用美沙酮的妇女的后代进行的多代纵向研究。我们收集了大量关于父母和孩子的数据，假设药物可以通过各种因果途径影响婴儿。我们使用了一种数据分析方法POSAC，它保留了单个儿童和家庭的身份，使我们能够查看个人随着时间的推移的行为模式，并确定有意义的个人亚群。我们从18名服用美沙酮的女性和24名对照女性那里收集了大量信息。在怀孕的最后三个月，我们采访了这些女性的教育、家庭、生活方式、药物使用和健康史；我们还评估了她们的精神功能和智商。我们发现，作为一个群体，服用美沙酮的女性比对照组女性更有可能接受公共援助，证明精神功能障碍，受教育程度较低(尽管智商没有统计学上的差异)。与对照女性相似，服用美沙酮的女性中有三分之二的人与男性伴侣保持稳定的关系。服用美沙酮的女性似乎致力于美沙酮治疗，总体来说，她们对怀孕持积极态度。尽管作为一个群体，服用美沙酮的妇女比对照组拥有更少的母体功能资源，但大约一半的服用美沙酮的妇女拥有至少足够的母体功能资源。
In order to examine alternatives to the hypothesis that any lasting damage to a child is caused by the direct toxic effects of fetal exposure to methadone, we designed a longitudinal, multigenerational study of the offspring of methadone-maintained women. We collected extensive data on both parents and children, hypothesizing that drugs can affect infants through a variety of causal routes. We have used a method of data analysis, POSAC, that retains the identity of individual children and families, and enables us to look at patterns of individuals' behavior over time and identify meaningful subgroups of individuals. We collected extensive information from 18 methadone-maintained and 24 comparison women. During the last trimester of pregnancy, we interviewed the women about their education, families, lifestyles, drug use, and health histories; we also assessed their psychiatric functioning and IQ's. We found that as a group the methadone-maintained women were more likely to receive public assistance, to evidence psychiatric dysfunctioning, and to be less educated (although showing no statistical difference in IQ's) than were comparison women. Similar to comparison women, two-thirds of methadone-maintained women were involved in stable relationships with male partners. The methadone-maintained women appeared committed to their methadone treatment and, in general, viewed their pregnancies in positive terms. Although as a group the methadone-maintained women possessed poorer resources for maternal functioning than the comparison group, about half the methadone-maintained women possessed resources at least adequate for maternal functioning.