THE DOPAMINE HYPOTHESIS OF THE REINFORCING PROPERTIES OF COCAINE
THE DOPAMINE HYPOTHESIS OF THE REINFORCING PROPERTIES OF COCAINE
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DOI：
10.1016/0166-2236(91)90141-g
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发表时间：
1991-07-01
影响因子：
15.9
通讯作者：
BOJA, JW
中科院分区：
文献类型：
--
作者：
KUHAR, MJ;RITZ, MC;BOJA, JW
各种证据表明，可卡因的强化特性存在“多巴胺假说”。这一假说认为可卡因与多巴胺转运蛋白结合，主要抑制神经递质的再摄取，从而增强中脑边缘皮质通路中的多巴胺能神经传递，最终导致强化。该模型表明了治疗可卡因滥用和依赖的潜在药物。一些但不是全部的人体药理学数据支持这一假设，需要进行额外的实验。
A variety of evidence suggests a 'dopamine hypothesis' for the reinforcing properties of cocaine. This hypothesis proposes that cocaine binds at the dopamine transporter and mainly inhibits neurotransmitter re-uptake; the resulting potentiation of dopaminergic neurotransmission in mesolimbocortical pathways ultimately causes reinforcement. This model suggests potential medications for treatment of cocaine abuse and dependence. Some, but not all, pharmacological data in humans support the hypothesis and additional experimentation is needed.