Effects of mechanosensitive ion channels on ventricular electrophysiology: experimental and theoretical models
Effects of mechanosensitive ion channels on ventricular electrophysiology: experimental and theoretical models
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DOI：
10.1113/expphysiol.2005.031062
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发表时间：
2006-03-01
影响因子：
2.7
通讯作者：
Garny, A
中科院分区：
文献类型：
--
作者：
Kohl, P;Bollensdorff, C;Garny, A
心脏是一个电力驱动的机械泵，有点像电动机。有趣的是，就像“发电机模式”的电动机一样，心脏也可以将机械刺激转换为电信号。从心脏力学到电活动的这种反馈涉及机械敏感离子通道，其性质和病理生理学相关性在心室逐拍电机械功能的实验和理论建模的背景下进行审查。
The heart is an electrically driven mechanical pump, somewhat like an electric motor. Interestingly, like an electric motor in 'dynamo mode', the heart can also convert mechanical stimuli into electrical signals. This feedback from cardiac mechanics to electrical activity involves mechanosensitive ion channels, whose properties and pathophysiological relevance are reviewed in the context of experimental and theoretical modelling of ventricular beat-by-beat electromechanical function.