Cocaine use is associated with a higher prevalence of elevated ST2 concentrations.
Cocaine use is associated with a higher prevalence of elevated ST2 concentrations.
复制标题
可卡因的使用与 ST2 浓度升高的发生率较高有关。
DOI：
10.1016/j.clinbiochem.2017.04.015
复制
发表时间：
2017
影响因子：
2.8
通讯作者：
Riley,EliseD
中科院分区：
文献类型：
--
作者：
vanWijk,XanderMR;Vittinghoff,Eric;Wu,AlanHB;Lynch,KaraL;Riley,EliseD
背景冠心病是一个众所周知的急性心脏事件的危险因素，但在急性事件以外的用户的影响不太清楚。我们调查了可卡因使用与心脏应激和心力衰竭的新型生物标志物ST 2浓度之间的可能关联。MethodsA病例对照研究通过在城市安全网医院接受治疗但不接受心脏治疗的患者中可卡因的存在来比较ST 2浓度。可卡因的存在与ST 2浓度> 35 ng/mL相关。苯甲酰芽子碱，可卡因的主要代谢产物，血清浓度显着相关性ST 2 concentrationsConclusionsCochlorine使用与亚临床心脏应激和急性心脏事件以外的损害。这些信息可以更好地对ST 2浓度升高的可卡因使用者进行分层，这些人可能有更高的心力衰竭和其他心脏并发症的风险。
BackgroundCocaine is a well-known risk factor for acute cardiac events, but the effects in users outside of acute events are less clear. We investigated a possible association between cocaine use and the concentration of a novel biomarker for cardiac stress and heart failure, ST2.MethodsA case-control study was conducted to compare ST2 concentrations by the presence of cocaine in patients presenting for care, but not cardiac care, at an urban safety net hospital.ResultsIn samples taken from 100 cocaine-positive and 100 cocaine-negative patients, the presence of cocaine was associated with ST2 concentrations > 35 ng/mL. Serum concentrations of benzoylecgonine, a major cocaine metabolite, were significantly correlated with ST2 concentrations.ConclusionsCocaine use is associated with subclinical cardiac stress and damage outside of acute cardiac events. This information could add to better stratification of cocaine users with elevated ST2 concentrations who may be at higher risk for developing heart failure and other cardiac complications.