Carbapenemase-producing Enterobacteriaceae in Europe: assessment by national experts from 38 countries, May 2015
Carbapenemase-producing Enterobacteriaceae in Europe: assessment by national experts from 38 countries, May 2015
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DOI：
10.2807/1560-7917.es.2015.20.45.30062
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发表时间：
2015-11-12
期刊：
影响因子：
19
通讯作者：
Monnet, D. L.
中科院分区：
文献类型：
--
作者：
Albiger, B.;Glasner, C.;Monnet, D. L.
2012年，欧洲疾病预防控制中心（ECDC）启动了“欧洲产碳青霉烯酶肠杆菌科调查（EuSCAPE）”项目，以深入了解产碳青霉烯酶肠杆菌科（CPE）的发生和流行病学，提高对CPE传播的认识，并建立和加强欧洲CPE诊断和监测的实验室能力。2015年5月通过EuSCAPE后反馈问卷收集的数据记录了与2013年相比，38个参与国家检测CPE和识别不同碳青霉烯酶基因的能力有所提高，从而有助于提高他们对CPE传播的认识和知识。在过去两年中，CPE的流行病学情况恶化，特别是随着碳青霉烯水解苯唑西林酶-48（OXA-48）和产新德里金属β内酰胺酶（NDM）的肠杆菌科的快速传播。2015年，38个国家中有13个国家报告了CPE的区域间传播或流行情况，而2013年为6/38。只有三个国家答复说，它们没有发现一例CPE。持续蔓延的CPE对欧洲医院的患者安全构成越来越大的威胁，大多数国家通过建立国家CPE监测系统和发布卫生专业人员控制措施指南来应对。然而，到2015年年中，仍有14个国家缺乏预防和控制CPE的具体国家指南。
In 2012, the European Centre for Disease Prevention and Control (ECDC) launched the 'European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE)' project to gain insights into the occurrence and epidemiology of carbapenemase-producing Enterobacteriaceae (CPE), to increase the awareness of the spread of CPE, and to build and enhance the laboratory capacity for diagnosis and surveillance of CPE in Europe. Data collected through a post-EuSCAPE feedback questionnaire in May 2015 documented improvement compared with 2013 in capacity and ability to detect CPE and identify the different carbapenemases genes in the 38 participating countries, thus contributing to their awareness of and knowledge about the spread of CPE. Over the last two years, the epidemiological situation of CPE worsened, in particular with the rapid spread of carbapenem-hydrolysing oxacillinase-48 (OXA-48)-and New Delhi metallo-betalactamase (NDM)-producing Enterobacteriaceae. In 2015, 13/38 countries reported inter-regional spread of or an endemic situation for CPE, compared with 6/38 in 2013. Only three countries replied that they had not identified one single case of CPE. The ongoing spread of CPE represents an increasing threat to patient safety in European hospitals, and a majority of countries reacted by establishing national CPE surveillances systems and issuing guidance on control measures for health professionals. However, 14 countries still lacked specific national guidelines for prevention and control of CPE in mid-2015.