Epithelial-to-Mesenchymal Transition in the Light of Plasticity and Hybrid E/M States.
Epithelial-to-Mesenchymal Transition in the Light of Plasticity and Hybrid E/M States.
复制标题
在可塑性和杂化E/M状态下，上皮到间质转变。
DOI：
10.3390/jcm10112403
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发表时间：
2021-05-29
影响因子：
3.9
通讯作者：
van Rheenen J
中科院分区：
文献类型：
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作者：
Bornes L;Belthier G;van Rheenen J
上皮-间充质转化（EMT）是一种细胞程序，其导致细胞失去上皮特征，包括细胞极性、细胞-细胞粘附和与基底膜的附着，同时获得间充质特征，如侵袭性和干性。该计划涉及胚胎发育，伤口愈合和癌症进展。多年来，EMT在癌症进展中的作用一直备受争议，甚至在转移中对该过程的要求也存在争议。在这篇综述中，我们讨论了以前的差异，根据最近的研究结果EMT，可塑性和混合E/M状态。此外，我们强调了各种肿瘤微环境的线索和细胞内在的信号转导途径，诱导和维持EMT程序，可塑性和混合E/M状态。最后，我们讨论了最近关于可塑性的研究结果，特别是那些使细胞能够在混合E/M状态之间切换的研究结果，改变了我们对EMT在癌症转移，干性和治疗抗性中的作用的理解。
Epithelial-to-mesenchymal transition (EMT) is a cellular program which leads to cells losing epithelial features, including cell polarity, cell–cell adhesion and attachment to the basement membrane, while gaining mesenchymal characteristics, such as invasive properties and stemness. This program is involved in embryogenesis, wound healing and cancer progression. Over the years, the role of EMT in cancer progression has been heavily debated, and the requirement of this process in metastasis even has been disputed. In this review, we discuss previous discrepancies in the light of recent findings on EMT, plasticity and hybrid E/M states. Moreover, we highlight various tumor microenvironmental cues and cell intrinsic signaling pathways that induce and sustain EMT programs, plasticity and hybrid E/M states. Lastly, we discuss how recent findings on plasticity, especially on those that enable cells to switch between hybrid E/M states, have changed our understanding on the role of EMT in cancer metastasis, stemness and therapy resistance.