THE EFFECT OF SPLANCHNIC NERVE-SECTION ON THE SENSITIVITY OF THE ADRENAL-CORTEX TO ADRENOCORTICOTROPIN IN THE CALF
THE EFFECT OF SPLANCHNIC NERVE-SECTION ON THE SENSITIVITY OF THE ADRENAL-CORTEX TO ADRENOCORTICOTROPIN IN THE CALF
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DOI：
10.1113/jphysiol.1987.sp016683
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发表时间：
1987-09-01
影响因子：
5.5
通讯作者：
JONES, CT
中科院分区：
文献类型：
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作者：
EDWARDS, AV;JONES, CT
1.为探讨内脏神经切断是否影响肾上腺皮质对促肾上腺皮质激素（ACTH）的敏感性，在2-6周龄清醒犊牛中，切断双侧内脏神经至少7天后，将其肾上腺皮质对ACTH的反应与同龄正常犊牛进行比较。2.在一系列实验中，通过静脉输注去甲肾上腺素（333 ng min-1 kg-1，持续10 min）引起内源性ACTH释放的增加，在另一系列实验中，通过静脉输注合成ACTH 1 -24（5或10 ng min-1 kg-1，持续10 min）人为增加血浆中ACTH的浓度。在所有组中，平均血浆促肾上腺皮质激素与平均血浆皮质醇呈线性相关，发现肾上腺类固醇生成反应对促肾上腺皮质激素的敏感性在切除两条内脏神经后7天或更长时间内大幅降低。
1. Adrenal cortical responses to adrenocorticotrophin (ACTH) in conscious 2-6-week-old calves, in which both splanchnic nerves had been cut at least 7 days previously, were compared with those of normal calves of the same age in order to discover whether splanchnic nerve section affects the sensitivity of the adrenal cortex to the trophin. 2. In one series of experiments an increase in the release of endogenous ACTH was elicited by an i.v. infusion of noradrenaline (333 ng min-1 kg-1 for 10 min) and in another the concentration of ACTH in the plasma was artificially increased by infusing synthetic ACTH1-24 intravenously at either 5 or 10 ng min-1 kg-1 for 10 min. 3. In all groups mean plasma ACTH was linearly related to mean plasma cortisol and the sensitivity of the adrenal steroidogenic response to ACTH was found to be substantially reduced 7 or more days after section of both splanchnic nerves.