Enhancement of High-Intensity Focused Ultrasound Heating by Short-Pulse Generated Cavitation
Enhancement of High-Intensity Focused Ultrasound Heating by Short-Pulse Generated Cavitation
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DOI：
10.3390/app7030288
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发表时间：
2017-03
期刊：
影响因子：
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通讯作者：
S. Yoshizawa;R. Takagi;S. Umemura
中科院分区：
文献类型：
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作者：
S. Yoshizawa;R. Takagi;S. Umemura
在高强度聚焦超声(HIFU)治疗中，可以无创地对靶组织进行热凝。HIFU热疗已在临床上应用于各种实体肿瘤。HIFU治疗中的一个问题是治疗时间过长。声学驱动的微泡可以加速超声加热，从而显著缩短处理时间。本文介绍了一种利用空化微泡进行“触发HIFU曝光”的方法，并对其结果进行了评述。触发HIFU序列由高强度短脉冲和中等强度长脉冲组成。通过快速扫描高强度脉冲焦点，在多焦点区域诱导空化气泡，显着提高了温升，并高效地产生了大范围的凝聚区域。
A target tissue can be thermally coagulated in high-intensity focused ultrasound (HIFU) treatment noninvasively. HIFU thermal treatments have been clinically applied to various solid tumors. One of the problems in HIFU treatments is a long treatment time. Acoustically driven microbubbles can accelerate the ultrasonic heating, resulting in the significant reduction of the treatment time. In this paper, a method named “trigger HIFU exposure” which employs cavitation microbubbles is introduced and its results are reviewed. A trigger HIFU sequence consists of high-intensity short pulses followed by moderate-intensity long bursts. Cavitation bubbles induced in a multiple focal regions by rapidly scanning the focus of high-intensity pulses enhanced the temperature increase significantly and produced a large coagulation region with high efficiency.