Time course of eosinophilic myocarditis visualized by CMR
Time course of eosinophilic myocarditis visualized by CMR
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DOI：
10.1186/1532-429x-10-21
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发表时间：
2008-05-08
影响因子：
6.4
通讯作者：
Luchner, Andreas
中科院分区：
文献类型：
--
作者：
Deb, Kurt;Djavidani, Behrus;Luchner, Andreas
我们报告心血管磁共振（CMR）的诊断潜力，以可视化的时间过程嗜酸性心肌炎成功治疗后。一名50岁男性因进行性心力衰竭入院。由于白细胞计数为17000/mm(3)，嗜酸性粒细胞占41%，左心室进行了心内膜活检。组织学检查显示心内膜嗜酸性粒细胞浸润及心肌细胞坏死。由于特发性嗜酸性粒细胞增多综合征，患者被诊断为嗜酸性粒细胞增多性心肌炎。首发时的cmr研究和3周后的随访研究显示整个左心室弥漫性心内膜下LGE。经类固醇治疗后，cmr研究显示，3个月后心内膜下LGE显著降低，临床进一步改善。因此，本病例强调了CMR在诊断和治疗嗜酸性心肌炎时观察心内膜受累程度的临床重要性。
We report the diagnostic potential of cardiovascular magnetic resonance (CMR) to visualize the time course of eosinophilic myocarditis upon successful treatment. A 50-year-old man was admitted with a progressive heart failure. Endomyocardial biopsies were taken from the left ventricle because of a white blood cell count of 17000/mm(3) with 41% eosinophils. Histological evaluation revealed endomyocardial eosinophilic infiltration and areas of myocyte necrosis. The patient was diagnosed with hypereosinophilic myocarditis due to idiopathic hypereosinophilic syndrome. CMR-studies at presentation and a follow-up study 3 weeks later showed diffuse subendocardial LGE in the whole left ventricle. Upon treatment with steroids, CMR-studies revealed marked reduction of subendocardial LGE after 3 months in parallel with further clinical improvement. This case therefore highlights the clinical importance of CMR to visualize the extent of endomyocardial involvement in the diagnosis and treatment of eosinophilic myocarditis.