ANTITUBULAR BASEMENT-MEMBRANE ANTIBODIES IN METHICILLIN-ASSOCIATED INTERSTITIAL NEPHRITIS
ANTITUBULAR BASEMENT-MEMBRANE ANTIBODIES IN METHICILLIN-ASSOCIATED INTERSTITIAL NEPHRITIS
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DOI：
10.1056/nejm197408222910803
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发表时间：
1974-01-01
影响因子：
158.5
通讯作者：
WILSON, CB
中科院分区：
文献类型：
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作者：
BORDER, WA;LEHMAN, DH;WILSON, CB
通过间接免疫荧光法在一名接受甲氧西林治疗期间发生严重肾功能衰竭的患者血清中检测到抗肾小管基底膜抗体。肾活检显示重度单核细胞间质浸润伴肾小管变性局灶性区域。IgG，C3和甲氧西林抗原假定为二甲氧基苯基青霉噻唑酰存在于沿着肾小管基底膜，但不是沿着肾小球基底膜的线性模式。二甲氧基苯基青霉噻唑酰-肾小管基底膜“半抗原蛋白缀合物”显然导致与参与患者间质性肾炎的免疫发病机制的抗肾小管基底膜抗体的免疫应答。（《新英格兰医学杂志》291：381-384，1974）
Antitubular basement-membrane antibodies were detected by indirect immunofluorescence in the serum of a patient in whom severe renal failure developed while he was receiving methicillin. A renal biopsy showed a severe mononuclear interstitial infiltrate with focal areas of tubular degeneration. IgG, C3 and a methicillin antigen assumed to be dimethoxyphenylpenicilloyl were present in a linear pattern along the tubular basement membrane but not along the glomerular basement membrane. The dimethoxyphenylpenicilloyl-tubular-basement-membrane "hapten protein conjugate" apparently led to an immune response with antitubular basement-membrane antibodies being involved in the immunopathogenesis of the patient's interstitial nephritis. (N Engl J Med 291:381–384, 1974)