Effects of estrogen on potassium-stimulated acetylcholine release in the hippocampus and overlying cortex of adult rats
Effects of estrogen on potassium-stimulated acetylcholine release in the hippocampus and overlying cortex of adult rats
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DOI：
10.1016/s0006-8993(96)01375-3
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发表时间：
1997-02-21
期刊：
影响因子：
2.9
通讯作者：
Johnson, DA
中科院分区：
文献类型：
--
作者：
Gibbs, RB;Hashash, A;Johnson, DA
在体内微透析技术被用来研究雌激素对钾刺激的乙酰胆碱释放在海马和覆盖的成年，卵巢切除大鼠皮质的影响。雌激素治疗导致钾诱导的乙酰胆碱释放的百分比变化相对于对照组显著增加，特别是在长时间（90分钟）暴露于高钾后。这些数据表明，雌激素可能有助于维持胆碱能功能的条件下，胆碱能传入海马结构和皮质受到挑战或受损。
In vivo microdialysis techniques were used to examine the effects of estrogen on potassium-stimulated acetylcholine release in the hippocampus and overlying cortex of adult, ovariectomized rats. Estrogen treatment resulted in a significant increase in the percent change in acetylcholine release induced by potassium relative to controls, particularly after prolonged (90 min) exposure to high potassium. The data suggest that estrogen may help to maintain cholinergic function under conditions where cholinergic afferents to the hippocampal formation and cortex are challenged or impaired.