Improving visualization of 4D flow cardiovascular magnetic resonance with four-dimensional angiographic data: generation of a 4D phase-contrast magnetic resonance CardioAngiography (4D PC-MRCA).
Improving visualization of 4D flow cardiovascular magnetic resonance with four-dimensional angiographic data: generation of a 4D phase-contrast magnetic resonance CardioAngiography (4D PC-MRCA).
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DOI：
10.1186/s12968-017-0360-8
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发表时间：
2017-06-23
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影响因子：
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通讯作者：
Ebbers T
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作者：
Bustamante M;Gupta V;Carlhäll CJ;Ebbers T
用于评估心血管形态的磁共振血管成像(MRA)和相位对比MRA(PC-MRA)方法通常会将包含整个心脏周期信息的数据合并到一个2D或3D图像中。然而，在这个过程中，特定于心脏周期每个时间段的信息会丢失。这项研究提出了一种新的技术，称为相位对比磁共振心脏血管成像(4D PC-MRCA)，该技术在生成时间分辨的PC-MRA数据时充分利用4D Flow CMR的潜力，以改进整个心脏周期中心脏和主要血管的可视化。利用4D Flow CMR采集时间范围之间的非刚性配准，该技术将整个心脏周期的信息集中到一个特定时间帧的血管造影数据集中，并考虑了整个心脏周期的运动。时间帧之间的配准再次用于生成时间分辨血管造影术。该方法在10名健康志愿者身上进行了评估。由两个观察者使用最大强度投影(MIP)对使用传统方法的4D Flow CMR生成的4D PC-MRCA和PC-MRA进行可视化比较。4DPC-MRCA能更好地显示心血管系统的主要解剖区域，特别是存在心脏或血管运动的区域。该方法是对以往基于4D Flow CMR的PC-MRA生成技术的改进，因为它有效地利用了采集中所有可用的信息。4DPC-MRCA可用于可视化心脏和主要血管在整个心脏周期中的运动。本文的在线版本(doi：10.1186/s12968-0170360-8)包含补充材料，授权用户可以使用。
Magnetic Resonance Angiography (MRA) and Phase-Contrast MRA (PC-MRA) approaches used for assessment of cardiovascular morphology typically result in data containing information from the entire cardiac cycle combined into one 2D or 3D image. Information specific to each timeframe of the cardiac cycle is, however, lost in this process. This study proposes a novel technique, called Phase-Contrast Magnetic Resonance CardioAngiography (4D PC-MRCA), that utilizes the full potential of 4D Flow CMR when generating temporally resolved PC-MRA data to improve visualization of the heart and major vessels throughout the cardiac cycle. Using non-rigid registration between the timeframes of the 4D Flow CMR acquisition, the technique concentrates information from the entire cardiac cycle into an angiographic dataset at one specific timeframe, taking movement over the cardiac cycle into account. Registration between the timeframes is used once more to generate a time-resolved angiography. The method was evaluated in ten healthy volunteers. Visual comparison of the 4D PC-MRCAs versus PC-MRAs generated from 4D Flow CMR using the traditional approach was performed by two observers using Maximum Intensity Projections (MIPs). The 4D PC-MRCAs resulted in better visibility of the main anatomical regions of the cardiovascular system, especially where cardiac or vessel motion was present. The proposed method represents an improvement over previous PC-MRA generation techniques that rely on 4D Flow CMR, as it effectively utilizes all the information available in the acquisition. The 4D PC-MRCA can be used to visualize the motion of the heart and major vessels throughout the entire cardiac cycle. The online version of this article (doi:10.1186/s12968-017-0360-8) contains supplementary material, which is available to authorized users.