Predictors of coronal caries progression in adults: results from the Prevention of Adult Caries Study.
Predictors of coronal caries progression in adults: results from the Prevention of Adult Caries Study.
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DOI：
10.1111/cdoe.12059
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发表时间：
2013-12
影响因子：
2.3
通讯作者：
Mabi L Singh;A. Papas;W. Vollmer;J. Bader;Reesa Laws;G. Maupomé;J. Snyder;P. Blanchard
中科院分区：
文献类型：
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作者：
Mabi L Singh;A. Papas;W. Vollmer;J. Bader;Reesa Laws;G. Maupomé;J. Snyder;P. Blanchard
对成人龋齿预防研究（PACS）数据的二次分析评估了冠状龋齿进展的风险因素。方法：参与者（n = 983）是龋齿风险增加的成年人，至少有一个空洞和一个非空洞病变，他们参加了一项随机临床试验，以测试10% w/v洗必泰清漆涂层对龋齿进展的影响。在基线和随机化后7个月和13个月，校准的检查者使用修改的国际龋齿检测和评估系统（ICDAS）分类对牙齿表面进行评分。在调整后的负二项回归模型中使用潜在的基线预测龋齿风险，以预测净D2 FS增量，并在线性回归模型中预测秩标准化净D12 FS增量。结果平均（SD）D2 FS和D12 FS增量分别为2.4（3.1）和2.1（6.9）。在多变量分析中，两个或多个基线D2病变，酸性饮料的消费，以及年龄的增加都与D2 FS和D12 FS风险增加显著相关。每天使用牙线也与D2 FS风险增加有关。基线时更频繁的牙科护理与两种增量的龋齿风险显著降低相关。结论：D12 FS和D2 FS模型中危险因素的总体一致性支持D1增量是完全空洞病变进展的中间阶段的假设。
OBJECTIVES This secondary analysis of data from the Prevention of Adult Caries Study (PACS) assesses risk factors for progression of coronal caries. METHODS Participants (n = 983) were adults at increased caries risk with at least one cavitated and one noncavitated lesions who were enrolled in a randomized clinical trial to test the effect of a 10% w/v chlorhexidine varnish coating on caries progression. Calibrated examiners scored tooth surfaces using a modified International Caries Detection and Assessment System (ICDAS) classification at baseline and at 7 and 13 months postrandomization. Potential baseline predictors of caries risk were used in adjusted negative binomial regression models to predict net D2FS increment and in linear regression models to predict the rank-normalized net D12FS increment. RESULTS Mean (SD) D2FS and D12FS increments were and 2.4 (3.1) and 2.1 (6.9), respectively. In multivariate analyses, two or more baseline D2 lesions, consumption of acidic drinks, and increasing age were all significantly associated with increased D2FS and D12FS risk. Daily flossing also was associated with increased D2FS risk. More frequent dental care at baseline was associated with significantly decreased caries risk for both increments. CONCLUSIONS The general concordance of risk factors in the D12FS and D2FS models lends support to the hypothesis that the D1 increment is an intermediate stage in the progression to fully cavitated lesions.