PEPTIDES CORRESPONDING TO A PREDICTIVE ALPHA-HELICAL DOMAIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GP41 ARE POTENT INHIBITORS OF VIRUS-INFECTION
PEPTIDES CORRESPONDING TO A PREDICTIVE ALPHA-HELICAL DOMAIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GP41 ARE POTENT INHIBITORS OF VIRUS-INFECTION
复制标题
DOI：
10.1073/pnas.91.21.9770
复制
发表时间：
1994-10-11
影响因子：
11.1
通讯作者：
MATTHEWS, TJ
中科院分区：
文献类型：
--
作者：
WILD, CT;SHUGARS, DC;MATTHEWS, TJ
为了确定HIV-1包膜蛋白在病毒感染中的作用，基于HIV-1跨膜蛋白gp 41的不同区域合成了一系列肽。这些肽之一DP-178对应于预测α-螺旋二级结构的区域（HIV-1（LAI）分离株的残基643-678），已被鉴定为有效的抗病毒剂。该肽在100 ℃时始终100%阻断病毒介导的细胞-细胞融合。
To define the role of the human immunodeficiency virus type 1 (HIV-1) envelope proteins in virus infection, a series of peptides were synthesized based on various regions of the HIV-1 transmembrane protein gp41. One of these peptides, DP-178, corresponding to a region predictive of alpha-helical secondary structure (residues 643-678 of the HIV-1(LAI) isolate), has been identified as a potent antiviral agent. This peptide consistently blocked 100% of virus-mediated cell-cell fusion at