New insights into the function of IAP proteins: modulation of the MYC/MAX/MAD network.
New insights into the function of IAP proteins: modulation of the MYC/MAX/MAD network.
复制标题
对 IAP 蛋白功能的新见解：MYC/MAX/MAD 网络的调节。
DOI：
10.1016/j.devcel.2007.12.015
复制
发表时间：
2008
影响因子：
11.8
通讯作者：
Duckett,ColinS
中科院分区：
文献类型：
--
作者：
Wright,CaseyW;Duckett,ColinS
越来越多的研究表明，凋亡抑制蛋白(IAP)除了抑制细胞凋亡外，还具有多种细胞功能。最近在《分子细胞》杂志上的一项研究表明，IAP成员c-IAP1通过触发Myc抑制蛋白Mad1的泛素化和蛋白酶体降解来增强Myc的活性。
A growing number of studies have revealed that the inhibitor of apoptosis (IAP) proteins play a variety of cellular roles in addition to suppression of apoptosis. A recent study inMolecular Celldemonstrates that one IAP member, c-IAP1, functions to potentiate the activity of Myc by triggering the ubiquitination and proteasomal degradation of the Myc inhibitory protein Mad1.