Immediate neural responses of appetitive motives and its relationship with hedonic appetite and body weight as revealed by magnetoencephalography.
Immediate neural responses of appetitive motives and its relationship with hedonic appetite and body weight as revealed by magnetoencephalography.
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DOI：
10.12659/msm.889234
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发表时间：
2013-08-02
期刊：
影响因子：
--
通讯作者：
Watanabe Y
中科院分区：
文献类型：
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作者：
Yoshikawa T;Tanaka M;Ishii A;Watanabe Y
我们的目的是确定与食物动机相关的大脑区域，并在禁食状态下使用脑磁图（MEG）检查个体差异。将MEG反应与食物功效量表（PFS）和体重指数（BMI）的子量表和总分进行相关分析。入组了8名健康右利手男性[年龄，29.0±10.4岁; BMI，22.7±2.4 kg/m2（平均值±SD）]。MEG实验包括2个食物阶段和2个对照阶段，以交替和平衡的顺序进行。在MEG记录期间，参与者观看了一组投射在屏幕上的食物图片（食物会话）或马赛克图片（控制会话）。当参与者观看食物的图片时，我们能够估计所有参与者的岛叶皮层中的等效电流偶极子（ECD）在每个图片呈现开始后约300 ms达到峰值。当他们观看马赛克图片时，8名参与者中有1名表现出相应的ECD。值得注意的是，MEG反应强度与因子1（食物可用）（r=0.846，P=0.008）和因子2（食物存在）（r=0.875，P=0.004）的子量表评分、PFS（r=0.820，P=0.013）和BMI（r=0.898，P=0.002）的总评分之间存在显著相关性。我们证明了岛叶皮层的直接神经反应参与食欲动机的个体差异。岛叶皮层的信号强度与食欲动机的自我意识有关。
We aimed to determine the brain areas related to food motivation and to examine individual variability using magnetoencephalography (MEG) during a fasted state. Correlation analysis was performed between MEG responses and the subscale and aggregated scores of the Power of Food Scale (PFS) and body mass index (BMI). Eight healthy, right-handed males [age, 29.0±10.4 years; BMI, 22.7±2.4 kg/m2 (mean ±SD)] were enrolled. The MEG experiment consisted of 2 food sessions and 2 control sessions in an alternating and counterbalanced order. During the MEG recordings, participants viewed a set of food pictures (food session) or mosaic pictures (control session) projected on a screen. When participants viewed pictures of food items, we were able to estimate equivalent current dipoles (ECDs) in the insular cortex in all participants peaked approximately 300 ms after the onset of each picture presentation. When they viewed mosaic pictures, 1 of 8 participants exhibited corresponding ECDs. Of note, significant correlations were observed between the intensities of the MEG responses and the subscale scores of Factor 1 (food available) (r=0.846, P=0.008) and those of Factor 2 (food present) (r=0.875, P=0.004), the aggregated scores of PFS (r=0.820, P=0.013), and BMI (r=0.898, P=0.002). We demonstrated the involvement of the immediate neural responses of the insular cortex in individual differences in appetitive motivation. The signal intensities of the insular cortex were associated with self-awareness of appetitive motive.