BIOCHEMICAL MARKERS OF SMOKE ABSORPTION AND SELF REPORTED EXPOSURE TO PASSIVE SMOKING
BIOCHEMICAL MARKERS OF SMOKE ABSORPTION AND SELF REPORTED EXPOSURE TO PASSIVE SMOKING
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DOI：
10.1136/jech.38.4.335
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发表时间：
1984-01-01
影响因子：
6.3
通讯作者：
SALLOOJEE, Y
中科院分区：
文献类型：
--
作者：
JARVIS, M;TUNSTALLPEDOE, H;SALLOOJEE, Y
在医院门诊就诊的非吸烟患者（100例）报告了他们在过去3天被动暴露于烟草烟雾的程度，并提供了血液、呼气、唾液和尿液样本。虽然绝对水平较低，但调查的所有身体隔室中的可替宁浓度与自我报告的暴露量系统相关。唾液尼古丁浓度也显示出与报告的暴露程度呈线性增加，尽管这一措施只对测试当天的暴露敏感。CO、硫氰酸盐和血浆尼古丁浓度的测量与暴露无关。数据表明，可替宁提供了被动吸烟暴露剂量的有效标记。尿液和唾液的非侵入性样本特别适合流行病学调查。详细的调查表项目也可能提供有价值的信息。
Non-smoking patients (100) attending hospital outpatient clinics reported their degree of passive exposure to tobacco smoke over the preceding 3 days and provided samples of blood, expired air, saliva and urine. Although the absolute levels were low, the concentration of cotinine in all body compartments surveyed was systematically related to self-reported exposure. Salivary nicotine concentration also showed a linear increase with degree of reported exposure, although this measure was sensitive only to exposure on the day of testing. Measures of CO, thiocyanate, and plasma nicotine concentrations were unrelated to exposure. The data indicate that cotinine provides a valid marker of the dose received from passive smoke exposure. The non-invasive samples of urine and saliva are particularly suited to epidemiological investigations. Detailed questionnaire items may also give valuable information.