Effects of long-term simulated microgravity on liver metabolism in rhesus macaques.
Effects of long-term simulated microgravity on liver metabolism in rhesus macaques.
复制标题
长期模拟微重力对恒河猴肝脏代谢的影响。
DOI：
10.1096/fj.202200544rr
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Qing Ge
中科院分区：
文献类型：
--
作者：
Beibei Zong;Yujia Wang;Jingyi Wang;Peng Zhang;Guanghan Kan;Mingyang Li;Juan Feng;Yifan Wang;Xiaoping Chen;Rong Jin;Qing Ge
The liver is an essential multifunctional organ and constantly communicates with nearly all the tissues in the body. Spaceflight or simulated microgravity has a significant impact on the livers of rodent models, including lipid accumulation and inflammatory cell infiltration. Whether similar liver lipotoxicity could occur in humans is not known, even though altered circulating cholesterol profile has been reported in astronauts. Using a 42-day head-down bed rest (HDBR) model in rhesus macaques, the present study investigated whether simulated microgravity alters the liver of non-human primates at the transcriptome and metabolome levels. Its association with stress and intestinal changes was also explored. Compared to the controls, the HDBR monkeys showed mild liver injury, elevated ANGPTL3 level in the plasma, and accumulation of fat vacuoles and inflammatory cells in the liver. Altered transcriptome signatures with up-regulation of genes in lipid metabolisms and down-regulation of genes in innate immune defense were also found in HDBR group-derived liver samples. The metabolic profiling of the liver revealed mildly disturbed fatty acid metabolism in the liver of HDBR monkeys. The intestinal dysbiosis, its associated endotoxemia and changes in the composition of bile acids, and elevated stress hormone in HDBR monkeys may contribute to the altered lipid metabolisms in the liver. These data indicate that liver metabolic functions and gut-liver axis should be closely monitored in prolonged spaceflight to facilitate strategy design to improve and maintain metabolic homeostasis.
