Distributed grey and white matter deficits in hyperkinetic disorder: MRI evidence for anatomical abnormality in an attentional network
Distributed grey and white matter deficits in hyperkinetic disorder: MRI evidence for anatomical abnormality in an attentional network
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DOI：
10.1017/s0033291701004706
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发表时间：
2001-11-01
影响因子：
6.9
通讯作者：
Taylor, E
中科院分区：
文献类型：
--
作者：
Overmeyer, S;Bullmore, ET;Taylor, E
背景先前对注意缺陷多动障碍（ADHD）儿童的神经影像学研究表明，额叶和纹状体灰质主要存在解剖和功能异常。在这里，我们报告使用新的图像分析方法，这不需要事先选择的区域的利益，以表征分布的形态缺陷的灰色和白色物质与ADHD。18名儿童患有ADHD的精细表型，他们也符合ICD-10多动障碍的标准（平均年龄10岁）。4岁）和16名正常儿童（平均年龄10（.）3年）进行比较，使用磁共振成像。两组在惯用手、性别、身高、体重和头围方面进行了匹配。通过在标准空间中的每个体素处拟合线性模型来估计组之间的形态差异，将阈值应用于所得到的体素统计图以生成空间上连续的阈上体素的簇，并通过重复随机重新排列数据来测试簇“质量”或每个2D簇中的阈上体素统计的总和。多动组右侧额上级回（Brodmann区（BA）8/9）、右侧扣带回后部（BA 30）和双侧基底节（尤其是右侧苍白球和壳核）灰质缺损明显。他们还表现出明显的中央白色物质赤字在左半球前锥体束和基底节上级。这种右半球空间分布的灰质缺陷模式与ADHD与大规模注意力神经认知网络中断相关的假设是一致的。左半球白色物质缺陷可能是由于髓鞘形成障碍。
Background. Previous neuroimaging studies of children with attention deficit hyperactivity disorder (ADHD) have demonstrated anatomic and functional abnormalities predominantly in frontal and striatal grey matter. Here we report the use of novel image analysis methods, which do not require prior selection of regions of interest, to characterize distributed morphological deficits of both grey and white matter associated with ADHD.Methods. Eighteen children with a refined phenotype of ADHD, who also met ICD-10 criteria for hyperkinetic disorder (mean age 10(.)4 years), and 16 normal children (mean age 10(.)3 years) were compared using magnetic resonance imaging. The groups were matched for handedness, sex, height, weight and head circumference. Morphological differences between groups were estimated by fitting a linear model at each voxel in standard space, applying a threshold to the resulting voxel statistic maps to generate clusters of spatially contiguous suprathreshold voxels, and testing cluster 'mass', or the sum of suprathreshold voxel statistics in each 2D cluster, by repeated random resampling of the data.Results. The hyperkinetic children had significant grey matter deficits in right superior frontal gyrus (Brodmann area (BA) 8/9), right posterior cingulate gyrus (BA 30) and the basal ganglia bilaterally (especially right globus pallidus and putamen). They also demonstrated significant central white matter deficits in the left hemisphere anterior to the pyramidal tracts and superior to the basal ganglia.Conclusions. This pattern of spatially distributed grey matter deficit in the right hemisphere is compatible with the hypothesis that ADHD is associated with disruption of a large scale neurocognitive network for attention. The left hemispheric white matter deficits may be due to dysmyelination.