Sites of endometrial vascular leakage during implantation in the rabbit.
Sites of endometrial vascular leakage during implantation in the rabbit.
复制标题
兔子植入过程中子宫内膜血管渗漏的部位。
DOI：
10.1002/ar.1092270107
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Hoos,PC
中科院分区：
文献类型：
--
作者：
Hoffman,LH;Winfrey,VP;Hoos,PC
用碳悬浮液标记血管，以确定子宫内膜血管显示大分子泄漏在植入部位的兔子。外渗首先见于植入部位子宫系膜面深层子宫内膜基质的静脉成分。碳标记在这些血管中在术后7天、0小时（p.c.）明显，并归因于内皮细胞之间的间隙形成。在植入过程的后期，在植入腔的侧壁和子宫反膜壁中观察到碳的微外渗。滋养层对血管的穿透是明显的，滋养层的膜状突起伸入血管腔。外渗的材料（碳，血小板）被定位到滋养层细胞内的膜的一个膜系统，并讨论了潜在的作用，迷宫在处理摄入的血浆成分。几小时后，在着床部位的子宫系膜方面也发生了类似的滋养层渗透血管的过程。全身给予抗炎剂吲哚美辛可阻断由于内皮间隙形成引起的血管渗漏，但对滋养层结穿透血管几乎没有影响。这一观察结果可以解释既往研究的结果，在这些研究中，抗炎药治疗降低了但不能完全抑制植入部位的血管通透性变化。
Vascular labelling with carbon suspension was used to identify endometrial vessels demonstrating macromolecular leakage at implantation sites in the rabbit. Extravasation was seen first in venous components of the deep endometrial stroma on the mesometrial aspect of implantation sites. Carbon labelling was apparent in such vessels at 7 d, 0 hr post coitum, (p.c.), and was attributed to gap formation between endothelial cells. Later in the implantation process, leakage was seen as microextravasations of carbon in the lateral and antimesometrial walls of implantation chambers. Here, penetration of vessels by trophoblast was apparent and membranous processes from the trophoblast projected into vessel lumina. Extravasated material (carbon, platelets) was localized to a labyrinthine system of membranes within the trophoblast, and a potential role for the labyrinth in handling of ingested plasma constituents is discussed. A similar process of trophoblastic penetration of vessels occurred on the mesometrial aspect of implantation sites several hours later. Systemic administration of the anti‐inflammatory agent indomethacin blocked vascular leakage due to endothelial gap formation but had little or no effect on trophoblast knob penetration of vessels. This observation may explain the results of previous studies in which treatment with anti‐inflammatory agents reduced, but could not inhibit completely, the vascular permeability changes at implantation sites.