A REEVALUATION OF ESTROGEN STATUS IN POSTMENOPAUSAL WOMEN WHO SMOKE
A REEVALUATION OF ESTROGEN STATUS IN POSTMENOPAUSAL WOMEN WHO SMOKE
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DOI：
10.1016/0002-9378(92)91617-j
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发表时间：
1992-05-01
影响因子：
9.8
通讯作者：
LOBO, RA
中科院分区：
文献类型：
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作者：
CASSIDENTI, DL;PIKE, MC;LOBO, RA
绝经后吸烟者雌激素水平低下被认为是降低子宫内膜癌风险和增加骨质疏松风险的机制。我们前瞻性地研究了一组匹配良好的吸烟者和非吸烟者，评估了他们的雌激素水平，并将他们与现有文献中的数据进行了比较。我们的结论是，肾上腺活动增加导致雄激素增加，主要是雄烯二酮，在绝经后吸烟者中可见，但雌激素水平没有下降。我们假设，与雌激素使用者不同，在不使用雌激素的人中，吸烟与雌激素水平的变化没有关联，其他机制肯定对所看到的流行病学观察负责。
Hypoestrogenism in postmenopausal smokers has been suggested as the mechanism for the observed decreased risk of endometrial cancer and increased risk of osteoporosis. We have prospectively studied a well-matched group of smokers and nonsmokers and have evaluated their estrogen levels and compared them with existing data from the literature. We conclude that increased adrenal activity resulting in increased androgens, mainly androstenedione, is seen in postmenopausal smokers but that estrogen levels are not decreased. We hypothesize that in nonusers, unlike in users of estrogen, smoking is not associated with changes in estrogen levels and that other mechanisms must be responsible for the epidemiologic observations seen.