Mineral-matrix interactions in bone and cartilage.
Mineral-matrix interactions in bone and cartilage.
复制标题
DOI：
10.1097/00003086-199208000-00041
复制
发表时间：
1992-08
影响因子：
4.2
通讯作者：
A. Boskey
中科院分区：
文献类型：
--
作者：
A. Boskey
矿物-基质相互作用调节骨和牙齿中羟基磷灰石的形成过程。在矿化组织中，许多阴离子大分子与矿物结合，通过这种结合，这些分子能够调节矿物晶体的大小和形状，确定初始晶体沉积的位置，并确定沉积的矿物晶体的类型。胶原蛋白，为羟基磷灰石沉积提供模板;细胞外基质囊泡，为晶体沉积提供受保护的环境;以及与羟基磷灰石具有高亲和力的非胶原基质蛋白均已被证明会影响体外矿化。一些非胶原蛋白已经被证明能够促进和抑制矿物质的形成和生长，这取决于它们的浓度以及它们在溶液中是固定的还是游离的。本文综述了目前对软骨内、膜内和附着骨形成中所涉及的矿物质-基质关系的认识，概述了矿物质沉积在哺乳动物钙化组织中的控制方式。的基质分子与羟基磷灰石的相互作用的结构基础，是在体外和原位数据暗示的基质分子与羟基磷灰石相互作用，以控制矿化。
Mineral-matrix interactions regulate the process of hydroxyapatite formation in bones and teeth. In mineralizing tissues, many anionic macromolecules bind to mineral. By means of this binding, such molecules are able to regulate the size and shape of the mineral crystals, determine the site of initial crystal deposition, and determine the type of mineral crystals deposited. Collagen, which provides a template for hydroxyapatite deposition; extracellular matrix vesicles, which provide a protected environment for crystal deposition; and noncollagenous matrix proteins that have high affinities for hydroxyapatite have all been shown to affect mineralization in vitro. Some of the noncollagenous proteins have been shown to be capable of promoting and inhibiting mineral formation and growth, depending on their concentration and whether they are immobilized or free in solution. This review surveys the current understanding of mineral-matrix relationships involved in endochondral, intramembranous, and appositional bone formation, outlining the way in which mineral deposition is controlled in mammalian calcified tissues. The structural basis for the interaction of the matrix molecules with hydroxyapatite is presented, as is the in vitro and in situ data implicating the matrix molecules that interact with hydroxyapatite to control mineralization.