Cobalt(I)-mediated [2 + 2 + 2] cyclization of allenediynes toward a diastereoselective approach to 11-aryl steroid skeletons.
Cobalt(I)-mediated [2 + 2 + 2] cyclization of allenediynes toward a diastereoselective approach to 11-aryl steroid skeletons.
复制标题
钴 (I) 介导的联二炔 [2 2 2] 环化，以非对映选择性方式形成 11-芳基类固醇骨架。
作者：
M. Petit;C. Aubert;M. Malacria
[反应：从反式联二炔以48%的总产率在C11和C10处同时引入取代基的一步中构建了11-芳基甾族骨架，而从顺式联二炔产生双环炔-三烯化合物的形式桤木烯反应成为主要过程。
[reaction: see text] An 11-aryl steroid skeleton has been built in one step with a simultaneous introduction of the substituents at both C11 and C10 in 48% overall yield from a trans-allenediyne, whereas a formal Alder ene reaction leading to a bicyclic yne-trienic compound becomes the major process from the cis-allenediyne.