Activity related to perceptual judgment and action in primary auditory cortex.
Activity related to perceptual judgment and action in primary auditory cortex.
复制标题
DOI：
10.1523/jneurosci.0767-11.2012
复制
发表时间：
2012-02-29
期刊：
影响因子：
--
通讯作者：
Sutter ML
中科院分区：
文献类型：
--
作者：
Niwa M;Johnson JS;O'Connor KN;Sutter ML
最近的证据是重塑初级听觉皮层（A1）的观点，从一个单一的区域，以一个更多的参与动态整合多感官和任务相关的信息。我们发现A1单（SU）和多单位（MU）活动与猕猴的选择在振幅调制（AM）的歧视任务。通过释放AM噪音控制杆并按住未调制噪音控制杆，训练动物区分AM噪音和未调制噪音。在动物报告AM的试验和它们没有报告AM的试验之间比较相同刺激的活性。我们发现47.4%的MU和22.8%的SU在动物报告AM的行为反应之前不久显著增加了放电，与AM未报告的试验的等效时间段相比。活动也与在不同的任务背景下的A1释放，这表明A1调制的体感，或传出复制，输入。当尖峰只在刺激过程中计数时，19.6%的MU和13.8%的SU在动物报告AM时增加了放电率，这表明了注意力效应，或者A1活动可以被更高的决策区域使用，或者这些区域向A1提供反馈。与AM报告相关的活动与单位的AM敏感性相关，表明AM敏感神经元参与任务执行。A1神经元对AM的锁相与动物对AM的报告相关性较弱（与放电率相比），这表明A1中的速率代码在AM辨别任务中具有优先作用。
Recent evidence is re-shaping the view of primary auditory cortex (A1) from a unisensory area to one more involved in dynamically integrating multisensory- and task-related information. We found A1 single- (SU) and multiple-unit (MU) activity correlated with macaques's choices in an amplitude modulation (AM) discrimination task. Animals were trained to discriminate AM-noise from unmodulated noise by releasing a lever for AM-noise and holding down the lever for unmodulated noise. Activity for identical stimuli was compared between trials where the animals reported AM and trials where they did not. We found 47.4% of MUs and 22.8% of SUs significantly increased firing shortly before the animal's behavioral response to report AM, when compared to the equivalent time period on trials where AM was not reported. Activity was also linked to lever-release in a different task context, suggesting A1 modulation by somatosensory, or efference-copy, input. When spikes were counted only during the stimulus, 19.6% of MUs and 13.8% of SUs increased firing rate when animals reported AM compared to when they did not, suggesting an attentional effect, or that A1 activity can be used by higher decision areas, or such areas provide feedback to A1. Activity associated with AM reporting was correlated with a unit's AM sensitivity, suggesting AM sensitive neurons’ involvement in task performance. A1 neurons’ phase-locking to AM correlated more weakly (compared to firing rate) with the animals’ report of AM, suggesting a preferential role for rate-codes in A1 for this AM discrimination task.