Photoinduced Aerobic Iodoarene-Catalyzed Spirocyclization of N-Oxy-amides to N-Fused Spirolactams**
Photoinduced Aerobic Iodoarene-Catalyzed Spirocyclization of N-Oxy-amides to N-Fused Spirolactams**
复制标题
DOI：
10.1002/anie.202009175
复制
发表时间：
2020-10-26
影响因子：
16.6
通讯作者：
Cariou, Kevin
中科院分区：
文献类型：
--
作者：
Habert, Loic;Cariou, Kevin
碘芳烃催化是一种强大的方法，通常需要过量的氧化剂，或者如果末端氧化剂是二氧，则需要氧化还原介质，以产生关键的高价碘中间体以有效地进行。我们报道，以酰胺的螺环化为基准反应，在蓝光照射下，依靠pyryum光催化剂可以实现好氧碘芳烃催化。这种前所未有的双有机催化系统允许在非常温和的操作条件下使用两种催化剂的低催化负荷。
Iodoarene catalysis is a powerful methodology that usually requires an excess of oxidant, or of redox mediator if the terminal oxidant is dioxygen, to generate the key hypervalent iodine intermediate to proceed efficiently. We report that, using the spiro-cyclization of amides as a benchmark reaction, aerobic iodoarene catalysis can be enabled by relying on a pyrylium photocatalyst under blue light irradiation. This unprecedented dual organocatalytic system allows the use of low catalytic loading of both catalysts under very mild operating conditions.