Saccharomyces boulardii CNCM I-745 changes lipidemic profile and gut microbiota in a hamster hypercholesterolemic model
Saccharomyces boulardii CNCM I-745 changes lipidemic profile and gut microbiota in a hamster hypercholesterolemic model
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DOI：
10.3920/bm2018.0134
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发表时间：
2019-01-01
影响因子：
5.4
通讯作者：
Roux, X.
中科院分区：
文献类型：
--
作者：
Briand, F.;Sulpice, T.;Roux, X.
高胆固醇血症是心血管疾病的主要危险因素。益生菌是一种安全的方法，可以降低胆固醇升高，对人体健康没有任何有害影响。布拉酵母CNCM I-745益生菌特性在肠道生态失调的背景下得到了很好的证明。最近的体外和临床前研究表明其对血脂异常的潜在作用。这是第一个对照研究调查S。布拉氏菌CNCM I-745对仓鼠高胆固醇血症模型中的血液分布和肠道微生物群的影响。每日给药（3g/kg）S.在饲喂0.3%胆固醇饲料的仓鼠中，布拉氏酵母菌21或39天显著降低血浆总胆固醇（P
Hypercholesterolemia is a main risk factor of cardiovascular disease. Probiotics are a safe approach to reduce elevated cholesterol without any deleterious effect to human health. Saccharomyces boulardii CNCM I-745 probiotic properties are well documented in a context of intestinal dysbiosis. Recent in vitro and preclinical studies have suggested its potential effects on dyslipidemia. This is the first controlled study investigating the effects of S. boulardii CNCM I-745 on lipidemic profile and gut microbiota in a hamster hypercholesterolemic model. Daily administration (3 g/kg) of S. boulardii for 21 or 39 days in hamsters fed a 0.3% cholesterol-diet significantly reduced total plasma cholesterol (P