Prediction of operons in microbial genomes
Prediction of operons in microbial genomes
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DOI：
10.1093/nar/29.5.1216
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发表时间：
2001-03-01
影响因子：
14.9
通讯作者：
Salzberg, SL
中科院分区：
文献类型：
--
作者：
Ermolaeva, MD;White, O;Salzberg, SL
操纵子结构是细菌基因组的一个重要组织特征。许多基因集在多个基因组中以相同的顺序出现；这些保守的基因分组代表了候选操纵子。本研究描述了一种计算方法：用于评估这些保守基因集形成操纵子的可能性。该方法被用于分析34个细菌和古细菌基因组，并得出了7600多对极有可能（P≥0.98）属于同一操纵子的基因。我们的方法对大肠杆菌基因组的敏感度为30 - 50%。预测的基因对可从我们的万维网网站http://www.tigr.org/tigr - scripts/operons/operons.cgi获取。
Operon structure is an important organization feature of bacterial genomes. Many sets of genes occur in the same order on multiple genomes; these conserved gene groupings represent candidate operons, This study describes a computational method: to estimate the likelihood that such conserved gene sets form operons. The method was used to-analyze 34 bacterial and archaeal genomes, and yielded more than 7600 pairs of genes that are highly likely (P greater than or equal to 0.98) to belong to the same operon. The sensitivity of our method is 30-50% for the Escherichia coli genome. The predicted gene pairs are available from our World Wide Web site http:// www.tigr.org/tigr-scripts/operons/operons.cgi.