V2-receptor-mediated relaxation of human renal arteries in response to desmopressin
V2-receptor-mediated relaxation of human renal arteries in response to desmopressin
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DOI：
10.1016/s0895-7061(98)00230-1
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发表时间：
1999-02-01
影响因子：
3.2
通讯作者：
Lluch, S
中科院分区：
文献类型：
--
作者：
Medina, P;Segarra, G;Lluch, S
本文观察了V-2受体抗利尿激动剂去氨基-8-D-精氨酸加压素对22例肾切除患者肾动脉分支离体环的作用。在去甲肾上腺素(10(-6)~3×10(-6)m ol/L)、去氨加压素(10(-11)~3×10(-7)m o l/L)的预收缩环中，血管内皮依赖性松弛(81%+/-4%逆转有内皮动脉的初始收缩；20%+/-4%无内皮动脉的收缩；P
The effects of deamino-8-D-arginine vasopressin (desmopressin), a V-2 receptor antidiuretic agonist, were studied in isolated rings from branches of renal arteries obtained from 22 patients undergoing nephrectomy. The rings were suspended in organ bath chambers for isometric recording of tension, in precontracted rings with norepinephrine (10(-6) to 3 x 10(-6) mol/L), desmopressin (10(-11) to 3 x 10(-7) mol/L) caused endothelium-dependent relaxation (81% +/- 4% reversal of the initial contraction in arteries with endothelium; 20% +/- 4% in arteries without endothelium; P