New functional single nucleotide polymorphism (Ala72Ser) in the COMT gene is associated with aggressive behavior in male schizophrenia
New functional single nucleotide polymorphism (Ala72Ser) in the COMT gene is associated with aggressive behavior in male schizophrenia
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DOI：
10.1002/ajmg.b.30649
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发表时间：
2008-07-05
影响因子：
2.8
通讯作者：
Kim, Chang Yoon
中科院分区：
文献类型：
--
作者：
Hong, Jin Pyo;Lee, Joongsun S.;Kim, Chang Yoon
一种新的功能性单核苷酸多态性。(SNP)COMT基因中的Ala 72 Ser是最近发现的。本研究旨在探讨COMT基因Ala 72 Ser和Vall 58 Met功能多态性与精神分裂症凶杀行为的关系。对93例精神分裂症患者（H-SCZ）和100例从未犯过杀人罪的精神分裂症患者（NH-SCZ）的COMT基因的Ala 72 Ser和Val 158 Met SNPs进行了基因分型。COMT基因Ala 72 Ser单核苷酸多态性在H-SCZ组和NH-SCZ组中的基因型分布和等位基因频率差异有统计学意义。在单倍型分析中，H-SCZ组高-高活性等位基因（Ala-Val）组合频率低于NH-SCZ组（P = 0.000069）。我们的研究表明，两个功能SNPs的COMT单倍型与精神分裂症的攻击行为之间存在高度显著的关联。(C)2007 Wiley-Liss，Inc.
A new functional single nucleotide polymorphism. (SNP) Ala72Ser in the COMT gene was discovered recently. The purpose of our study is to examine the association between Ala72Ser and Vall58Met functional polymorphisms in COMT gene and homicidal behavior in schizophrenia. DNA was genotyped for the Ala72Ser and Val158Met SNPs of the COMT gene in a sample of 93 schizophrenic patients who committed homicide (H-SCZ) and 100 schizophrenic patients who had never committed homicide (NH-SCZ). A statistically significant difference was found in genotype distribution and allele frequencies in SNP Ala72Ser of COMT gene between H-SCZ and NH-SCZ group. In haplotype analysis, the frequency of the combination of high-high activity allele (Ala-Val) was lower in H-SCZ group than in NH-SCZ group (P = 0.000069). Our study showed a highly significant association between a COMT haplotype of two functional SNPs and aggressive behavior in schizophrenia. (C) 2007 Wiley-Liss, Inc.