CORRELATION OF MAGNETIZATION-TRANSFER RATIO WITH CLINICAL DISABILITY IN MULTIPLE-SCLEROSIS
CORRELATION OF MAGNETIZATION-TRANSFER RATIO WITH CLINICAL DISABILITY IN MULTIPLE-SCLEROSIS
复制标题
DOI：
10.1002/ana.410360113
复制
发表时间：
1994-07-01
影响因子：
11.2
通讯作者：
MILLER, DH
中科院分区：
文献类型：
--
作者：
GASS, A;BARKER, GJ;MILLER, DH
我们对 43 名多发性硬化症 (MS) 患者、10 名年龄匹配的对照者和 4 名放射学诊断为小血管疾病的无症状老年患者进行了应用或不应用偏共振饱和脉冲的自旋回波磁共振成像。由此获得磁化转移（MT）比率图像。所有 MS 亚组（原发进展型、继发进展型、良性、早期复发缓解型）的平均病变 MT 比率均显着低于小血管疾病患者。继发进展性多发性硬化症患者的病变 MT 比率显着低于良性疾病患者，并且残疾与平均病变 MT 比率呈负相关。 MT 比率降低的程度是组织破坏程度的指标。因此，MS 中 MT 比率的降低可以指示脱髓鞘和轴突损失的程度，这两者都可能导致 MS 的功能缺陷。我们的结论是，MT 测量是（1）一种稳健的定量方法，可以提高磁共振成像的病理特异性，（2）有可能区分 MS 中的脱髓鞘与破坏性较小的病理变化，（3）可能有助于监测治疗引起的组织结构的变化。
We performed spin echo magnetic resonance imaging with and without application of an off-resonance saturation pulse in 43 patients with multiple sclerosis (MS), 10 age-matched controls, and 4 elderly asymptomatic patients with the radiological diagnosis of small-vessel disease. Magnetization transfer (MT) ratio images were obtained from these. All MS subgroups (primary progressive, secondary progressive, benign, early relapsing-remitting) showed significantly lower average lesion MT ratios than small-vessel disease patients. Secondary progressive MS patients showed significantly lower lesion MT ratios than those with benign disease, and there was an inverse correlation of disability with average lesion MT ratio. The degree of reduction of MT ratios is an indicator of the extent of tissue destruction. Thus, reduced MT ratios in MS may provide an indication of the degree of demyelination and axonal loss, both of which are likely to cause functional deficits in MS. We conclude that MT measurement is (1) a robust quantitative method that may increase the pathological specificity of magnetic resonance imaging, (2) has the potential to differentiate demyelination in MS from less destructive pathological changes, and (3) may be useful in monitoring modifications in tissue structure brought about by treatment.