Interleukin 1-driven secretion of interleukin 2 is highly temperature-dependent.
Interleukin 1-driven secretion of interleukin 2 is highly temperature-dependent.
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DOI：
10.4049/jimmunol.138.11.3808
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发表时间：
1987-06
影响因子：
4.4
通讯作者：
H. Lederman;C. Brill;P. Murphy
中科院分区：
文献类型：
--
作者：
H. Lederman;C. Brill;P. Murphy
To investigate the temperature dependence of T lymphocyte activation, we have examined the IL 1-induced secretion of IL 2 by the murine T lymphoma cell line LBRM-33-1A5. During 24-hr incubations, there are modest increases in IL 2 secretion as culture temperatures are increased from 33 degrees to 37 degrees C, but IL 2 secretion declines at higher temperatures. However, the kinetics of IL 2 release during the first 8 hr of culture are highly temperature-dependent. The rate of IL 2 release increases linearly with temperature over the range from 33 degrees to 41 degrees C, demonstrating temperature coefficients (Q10) greater than 70. In contrast, IL 2-promoted proliferation of a continuous T cell line is much less temperature-dependent with Q10 values of less than 4.0.
