Carrageenan-oligochitosan microcapsules: optimization of the formation process
Carrageenan-oligochitosan microcapsules: optimization of the formation process
复制标题
DOI：
10.1016/s0927-7765(00)00211-3
复制
发表时间：
2001-08-01
影响因子：
5.8
通讯作者：
Hunkeler, D
中科院分区：
文献类型：
--
作者：
Bartkowiak, A;Hunkeler, D
本文研究了卡拉胶与壳寡糖的复合微胶囊的形成。对工艺进行了优化，包括溶剂的选择和反应条件对胶囊性能的影响。I-角叉菜胶（1.2- 2%wt.）发现在HEPES缓冲液中制备的胶囊最适合于形成机械稳定的胶囊。这些新型胶囊联合收割机将极高的变形性（>90%）和弹性与渗透性控制相结合，并且可以应用于各种生物封装技术。结果表明，反应时间影响机械性能，而卡拉胶浓度和温度在胶囊形成过程中影响膜的机械和孔隙率特性。此外，温度影响通过复合物i-卡拉胶/低聚壳聚糖膜的扩散动力学。一般来说，在溶胶-凝胶转变点以上，逸出更快，表明在热诱导释放系统中的适用性。(C)2001 Elsevier Science B. V.保留所有权利。
The formation of new microcapsules based on polyelectrolyte complexes between carrageenans and oligochitosan has been investigated. The optimization of the process, which includes the selection of the most suitable solvent and investigation of the influence of reaction conditions on capsule properties, is presented. Iota-carrageenan (1.2-2% wt.) prepared in HEPES buffer was found to be the most suitable for the formation of mechanically stable capsules. These new capsules combine extremely high deformability (>90%) and elasticity with permeability control and can be applied in various bioencapsulation technologies. It has been shown that the reaction time influences the mechanical properties, whereas carrageenan concentration and the temperature during the capsule formation effect both mechanical and porosity characteristic of the membrane. Moreover, the temperature influences the kinetics of the diffusion through the complex iota-carrageenan/oligochitosan membrane. In general egress is faster above the sol-gel transition point, indicating applicability in thermo-induced releasing systems. (C) 2001 Elsevier Science B.V. All rights reserved.