Preparation and Characterization of Collagen–Chitosan–Chondroitin Sulfate Composite Membranes

Preparation and Characterization of Collagen–Chitosan–Chondroitin Sulfate Composite Membranes
复制标题

DOI：
10.1007/s00232-012-9442-6
复制
发表时间：
2012-06
期刊：
The Journal of Membrane Biology
影响因子：
--
通讯作者：
Kangjian Wang;Dan Nianhua;Shiwei Xiao;Yichun Ye;Dan Weihua
Kangjian Wang;Dan Nianhua;Shiwei Xiao;Yichun Ye;Dan Weihua
中科院分区：
其他
文献类型：
--
作者：
Kangjian Wang;Dan Nianhua;Shiwei Xiao;Yichun Ye;Dan Weihua

文献摘要

被引文献

相似文献

Collagen (Col)–chitosan (Chi) membrane was modified by a hot dehydrogenation cross-linking method. Carbodiimide was added for further crossing modification. Chondroitin sulfate (CS) was added so that Col–Chi sulfate composite membranes were prepared. The structure of the composite membranes was characterized by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, and its mechanical properties, degradation, and cytotoxicity were characterized. The composite membrane was applied to a full-thickness skin injury in animal experiments performed in rabbits. Strong interactions and good compatibility among Col, Chi, and CS in the composite membrane were present. The good mechanical properties, biocompatibility, digestion resistance, and wound healing promotion of the composite membrane make it a potential wound dressing or skin scaffold for tissue engineering.